Journal article
Degradable polyphosphazene/poly( α-hydroxyester) blends: degradation studies
Biomaterials, v 23(7), pp 1667-1672
2002
PMID: 11924588
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Biomaterials based on the polymers of lactic acid and glycolic acid and their copolymers are used or studied extensively as implantable devices for drug delivery, tissue engineering and other biomedical applications. Although these polymers have shown good biocompatibility, concerns have been raised regarding their acidic degradation products, which have important implications for long-term implantable systems. Therefore, we have designed a novel biodegradable polyphosphazene/poly(
α-hydroxyester) blend whose degradation products are less acidic than those of the poly(
α-hydroxyester) alone. In this study, the degradation characteristics of a blend of poly(lactide-
co-glycolide) (50
:
50 PLAGA) and poly[(50% ethyl glycinato)(50%
p-methylphenoxy) phosphazene] (PPHOS-EG50) were qualitatively and quantitatively determined with comparisons made to the parent polymers. Circular matrices (14
mm diameter) of the PLAGA, PPHOS-EG50 and PLAGA–PPHOS-EG50 blend were degraded in non-buffered solutions (pH 7.4). The degraded polymers were characterized for percentage mass loss and molecular weight and the degradation medium was characterized for acid released in non-buffered solutions. The amounts of neutralizing base necessary to bring about neutral pH were measured for each polymer or polymer blend during degradation. The poly(phosphazene)/poly(lactide-
co-glycolide) blend required significantly less neutralizing base in order to bring about neutral solution pH during the degradation period studied. The results indicated that the blend degraded at a rate intermediate to that of the parent polymers and that the degradation products of the polyphosphazene neutralized the acidic degradation products of PLAGA. Thus, results from these in vitro degradation studies suggest that the PLAGA–PPHOS-EG50 blend may provide a viable improvement to biomaterials based on acid-releasing organic polymers.
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Details
- Title
- Degradable polyphosphazene/poly( α-hydroxyester) blends: degradation studies
- Creators
- Archel M.A Ambrosio - Drexel UniversityHarry R Allcock - Pennsylvania State UniversityDhirendra S. Katti - Drexel UniversityCato T Laurencin - Drexel University
- Publication Details
- Biomaterials, v 23(7), pp 1667-1672
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000174196100013
- Scopus ID
- 2-s2.0-0036533091
- Other Identifier
- 991019339699704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials