Journal article
Delayed Exercise Is Ineffective at Reversing Aberrant Nociceptive Afferent Plasticity or Neuropathic Pain After Spinal Cord Injury in Rats
Neurorehabilitation and neural repair, v 30(7), pp 685-700
01 Aug 2016
PMID: 26671215
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neuropathic pain is a debilitating consequence of spinal cord injury (SCI) that correlates with sensory fiber sprouting. Recent data indicate that exercise initiated early after SCI prevents the development of allodynia and modulated nociceptive afferent plasticity. This study determined if delaying exercise intervention until pain is detected would similarly ameliorate established SCI-induced pain. Adult, female Sprague-Dawley rats with a C5 unilateral contusion were separated into SCI allodynic and SCI non-allodynic cohorts at 14 or 28 days postinjury when half of each group began exercising on automated running wheels. Allodynia, assessed by von Frey testing, was not ameliorated by exercise. Furthermore, rats that began exercise with no allodynia developed paw hypersensitivity within 2 weeks. At the initiation of exercise, the SCI Allodynia group displayed marked overlap of peptidergic and non-peptidergic nociceptive afferents in the C7 and L5 dorsal horn, while the SCI No Allodynia group had scant overlap. At the end of 5 weeks of exercise both the SCI Allodynia and SCI No Allodynia groups had extensive overlap of the 2 c-fiber types. Our findings show that exercise therapy initiated at early stages of allodynia is ineffective at attenuating neuropathic pain, but rather that it induces allodynia-aberrant afferent plasticity in previously pain-free rats. These data, combined with our previous results, suggest that there is a critical therapeutic window when exercise therapy may be effective at treating SCI-induced allodynia and that there are postinjury periods when exercise can be deleterious.
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Details
- Title
- Delayed Exercise Is Ineffective at Reversing Aberrant Nociceptive Afferent Plasticity or Neuropathic Pain After Spinal Cord Injury in Rats
- Creators
- Megan Ryan Detloff - Drexel University, College of MedicineDaniel Quiros-Molina - Drexel University, College of MedicineAmy S. Javia - Drexel University, College of MedicineLekhaj Daggubati - Drexel University, College of MedicineAnthony D. Nehlsen - Drexel University, College of MedicineAli Naqvi - Drexel University, College of MedicineVinu Ninan - Drexel University, College of MedicineKirsten N. Vannix - Drexel University, College of MedicineMary-Katharine McMullen - Drexel University, College of MedicineSheena Amin - Drexel University, College of MedicinePatrick D. Ganzer - The University of Texas at DallasJohn D. Houle - Drexel University, College of Medicine
- Publication Details
- Neurorehabilitation and neural repair, v 30(7), pp 685-700
- Publisher
- Sage
- Number of pages
- 16
- Grant note
- 2707 / Paralyzed Veterans of America Fritz Krauth Memorial Fellowship P01NS055976 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Drexel University College of Medicine Summer Medical Student Research Fellowships 220798 / Craig H. Neilsen Foundation Fellowship NS 55976 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000380937600009
- Scopus ID
- 2-s2.0-84978141428
- Other Identifier
- 991019168139504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Rehabilitation