Logo image
Back
Delayed suppression of hippocampal cell proliferation in rats following inescapable shocks
Journal article   Open access   Peer reviewed

Delayed suppression of hippocampal cell proliferation in rats following inescapable shocks

Casimir A. Fornal, Joanne Stevens, Jessica R. Barson, Gregory G. Blakley, Patricia Patterson-Buckendahl and Barry L. Jacobs
Brain research, v 1130(1)
2007
DOI: https://doi.org/10.1016/j.brainres.2006.10.081
PMID: 17161390
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc2785219View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

BrdU Corticosterone Dentate gyrus Neurogenesis Rat Stress
Adult Sprague-Dawley rats were exposed to a single session of 100 inescapable tail shocks (IS). Bromodeoxyuridine (BrdU) was administered 1 h, 2 days or 7 days later and hippocampal cell proliferation (CP) was assessed after a 2-h survival period. Measures of plasma corticosterone (CORT) levels were also obtained. Despite a large increase in CORT immediately following IS, no associated change in CP was observed. In fact, the only significant change in CP was seen 7 days after IS, at a time when CORT was unchanged from control levels. These data raise questions about the general nature of the relationship between CORT and CP. They also suggest that, under some conditions, changes in hippocampal CP may emerge only after an “incubation period”.

Metrics

8 Record Views
14 citations in Web of Science
16 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Neurosciences
Logo image