Journal article
Delineating the Diversity of Spinal Interneurons in Locomotor Circuits
The Journal of neuroscience, v 37(45), pp 10835-10841
08 Nov 2017
PMID: 29118212
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Locomotion is common to all animals and is essential for survival. Neural circuits located in the spinal cord have been shown to be necessary and sufficient for the generation and control of the basic locomotor rhythm by activating muscles on either side of the body in a specific sequence. Activity in these neural circuits determines the speed, gait pattern, and direction of movement, so the specific locomotor pattern generated relies on the diversity of the neurons within spinal locomotor circuits. Here, we review findings demonstrating that developmental genetics can be used to identify populations of neurons that comprise these circuits and focus on recent work indicating that many of these populations can be further subdivided into distinct subtypes, with each likely to play complementary functions during locomotion. Finally, we discuss data describing the manner in which these populations interact with each other to produce efficient, task-dependent locomotion.
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Details
- Title
- Delineating the Diversity of Spinal Interneurons in Locomotor Circuits
- Creators
- Simon Gosgnach - University of AlbertaJay B Bikoff - Columbia UniversityKimberly J Dougherty - Drexel UniversityAbdeljabbar El Manira - Karolinska InstituteGuillermo M Lanuza - Fundación Instituto LeloirYing Zhang - Dalhousie University
- Publication Details
- The Journal of neuroscience, v 37(45), pp 10835-10841
- Publisher
- Society for Neuroscience
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000414662100008
- Scopus ID
- 2-s2.0-85033604574
- Other Identifier
- 991019168704004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences