Journal article
Delivering CRISPR to the HIV-1 reservoirs
Frontiers in microbiology, v 15
01 May 2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human immunodeficiency virus type 1 (HIV-1) infection is well known as one of the most complex and difficult viral infections to cure. The difficulty in developing curative strategies arises in large part from the development of latent viral reservoirs (LVRs) within anatomical and cellular compartments of a host. The clustered regularly interspaced short palindromic repeats/ CRISPR-associated protein 9 (CRISPR/Cas9) system shows remarkable potential for the inactivation and/or elimination of integrated proviral DNA within host cells, however, delivery of the CRISPR/Cas9 system to infected cells is still a challenge. In this review, the main factors impacting delivery, the challenges for delivery to each of the LVRs, and the current successes for delivery to each reservoir will be discussed.
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Details
- Title
- Delivering CRISPR to the HIV-1 reservoirs
- Creators
- Theodore E. Gurrola - Drexel UniversitySamuel N. Effah - Drexel UniversityIlker K. Sariyer - Temple UniversityWill Dampier - Drexel UniversityMichael R. Nonnemacher - Drexel UniversityBrian Wigdahl - Drexel University
- Publication Details
- Frontiers in microbiology, v 15
- Publisher
- Frontiers Media S.A
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:001233412600001
- Scopus ID
- 2-s2.0-85194773466
- Other Identifier
- 991021880283304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Microbiology