Journal article
Delta and Egfr expression are regulated by Importin-7/Moleskin in Drosophila wing development
Developmental biology, v 308(2), pp 534-546
2007
PMID: 17628519
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Drosophila DIM-7 (encoded by the
moleskin gene,
msk) is the orthologue of vertebrate Importin-7. Both Importin-7 and Msk/DIM-7 function as nuclear import cofactors, and have been implicated in the control of multiple signal transduction pathways, including the direct nuclear import of the activated (phosphorylated) form of MAP kinase. We performed two genetic deficiency screens to identify deficiencies that similarly modified Msk overexpression phenotypes in both eyes and wings. We identified 11 total deficiencies, one of which removes the
Delta locus. In this report, we show that
Delta loss-of-function alleles dominantly suppress Msk gain-of-function phenotypes in the developing wing. We find that Msk overexpression increases both Delta protein expression and
Delta transcription, though Msk expression alone is not sufficient to activate Delta protein function. We also find that Msk overexpression increases Egfr protein levels, and that
msk gene function is required for proper Egfr expression in both developing wings and eyes. These results indicate a novel function for Msk in Egfr expression. We discuss the implications of these data with respect to the integration of Egfr and Delta/Notch signaling, specifically through the control of MAP kinase subcellular localization.
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Details
- Title
- Delta and Egfr expression are regulated by Importin-7/Moleskin in Drosophila wing development
- Creators
- Alysia D Vrailas-Mortimer - Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USANeena Majumdar - Department of Biological Sciences, University of the Sciences in Philadelphia, STC 271, 600 S. 43rd St., Philadelphia, PA 19104, USAGinnene Middleton - Department of Biological Sciences, University of the Sciences in Philadelphia, STC 271, 600 S. 43rd St., Philadelphia, PA 19104, USAEvan M Cooke - Department of Biological Sciences, University of the Sciences in Philadelphia, STC 271, 600 S. 43rd St., Philadelphia, PA 19104, USADaniel R Marenda - Department of Biological Sciences, University of the Sciences in Philadelphia, STC 271, 600 S. 43rd St., Philadelphia, PA 19104, USA
- Publication Details
- Developmental biology, v 308(2), pp 534-546
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000248890700024
- Scopus ID
- 2-s2.0-34547678501
- Other Identifier
- 991014877837704721
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- Web of Science research areas
- Developmental Biology