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Dementia with Lewy bodies
Journal article   Peer reviewed

Dementia with Lewy bodies

Ian McKeith, Jacobo Mintzer, Dag Aarsland, David Burn, Helen Chiu, Jiska Cohen-Mansfield, Dennis Dickson, Bruno Dubois, John E Duda, Howard Feldman, …
Lancet neurology, v 3(1)
Jan 2004
DOI: https://doi.org/10.1016/S1474-4422(03)00619-7
PMID: 14693108
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Alzheimer Disease - pathology Alzheimer Disease - physiopathology Brain - diagnostic imaging Brain - pathology Clinical Trials as Topic Diagnosis, Differential Humans Lewy Body Disease - diagnosis Lewy Body Disease - pathology Lewy Body Disease - physiopathology Lewy Body Disease - therapy Magnetic Resonance Imaging Parkinson Disease - pathology Parkinson Disease - physiopathology Radiography Tomography, Emission-Computed, Single-Photon Treatment Outcome
Dementia with Lewy bodies (DLB) is the second commonest cause of neurodegenerative dementia in older people. It is part of the range of clinical presentations that share a neuritic pathology based on abnormal aggregation of the synaptic protein alpha-synuclein. DLB has many of the clinical and pathological characteristics of the dementia that occurs during the course of Parkinson's disease. Here we review the current state of scientific knowledge on DLB. Accurate identification of patients is important because they have specific symptoms, impairments, and functional disabilities that differ from those of other common types of dementia. Severe neuroleptic sensitivity reactions are associated with significantly increased morbidity and mortality. Treatment with cholinesterase inhibitors is well tolerated by most patients and substantially improves cognitive and neuropsychiatric symptoms. Clear guidance on the management of DLB is urgently needed. Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life.

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583 citations in Web of Science
684 citations in Scopus

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Domestic collaboration
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Web of Science research areas
Clinical Neurology
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