Journal article
Dementia with Lewy bodies
Lancet neurology, v 3(1)
Jan 2004
PMID: 14693108
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dementia with Lewy bodies (DLB) is the second commonest cause of neurodegenerative dementia in older people. It is part of the range of clinical presentations that share a neuritic pathology based on abnormal aggregation of the synaptic protein alpha-synuclein. DLB has many of the clinical and pathological characteristics of the dementia that occurs during the course of Parkinson's disease. Here we review the current state of scientific knowledge on DLB. Accurate identification of patients is important because they have specific symptoms, impairments, and functional disabilities that differ from those of other common types of dementia. Severe neuroleptic sensitivity reactions are associated with significantly increased morbidity and mortality. Treatment with cholinesterase inhibitors is well tolerated by most patients and substantially improves cognitive and neuropsychiatric symptoms. Clear guidance on the management of DLB is urgently needed. Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life.
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Details
- Title
- Dementia with Lewy bodies
- Creators
- Ian McKeith - Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK. i.g.mckeith@ncl.ac.ukJacobo MintzerDag AarslandDavid BurnHelen ChiuJiska Cohen-MansfieldDennis DicksonBruno DuboisJohn E DudaHoward FeldmanSerge GauthierGlenda HallidayBrian LawlorCarol LippaOscar L LopezJoão Carlos MachadoJohn O'BrienJeremy PlayferWayne ReidInternational Psychogeriatric Association Expert Meeting on DLB
- Publication Details
- Lancet neurology, v 3(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000187447100022
- Scopus ID
- 2-s2.0-9144224226
- Other Identifier
- 991019312471204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology