Journal article
Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers
Clinical gastroenterology and hepatology, v 3(3), pp 225-230
2005
PMID: 15765441
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background & aims:
Risk factors for subtypes of esophageal and gastric cancer recently have been identified, but their effect on survival is unknown.
Methods:
Incident cases (n = 1142) from a population-based case-control study were followed-up from diagnosis (1993–1995) until 2000. Cox regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for esophageal and gastric cancer in relation to prediagnostic factors.
Results:
Relative to distant stage, esophageal adenocarcinoma (EA) patients with localized disease had a decreased risk for death (HR, .22; 95% CI, .15–.31), followed by those with regional spread (HR, .32; 95% CI, .23–.45). Similar patterns were seen for the other tumor types. Except for other (non-cardia) gastric adenocarcinomas (OGA), higher household income (≥$15,000/y vs. <$15,000/y) was associated with a 33%–38% decrease in risk for death. Prediagnosis body mass index (BMI) between 25 and 29.9 kg/m
2 was associated with longer survival for EA and OGA patients (EA: HR, .67; 95% CI, .51–.88) vs. BMI <25 kg/m
2. Women with esophageal squamous cell carcinoma (ES) and OGA experienced longer survival compared with men. Age, education, cigarette smoking, alcohol intake, gastroesophageal reflux disease, and nonsteroidal anti-inflammatory drug use did not consistently predict survival.
Conclusions:
Predictors of lengthened esophageal and gastric cancer survival included higher income (except in OGA), overweight (among EA and OGA patients), and female sex (among ES and OGA patients).
Metrics
Details
- Title
- Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers
- Creators
- Katrina F. Trivers - National Institutes of HealthAnneclaire J. de Roos - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaMarilie D. Gammon - University of North Carolina at Chapel HillThomas L. Vaughan - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaHarvey A. Risch - Yale UniversityAndrew F. Olshan - University of North Carolina at Chapel HillJanet B. Schoenberg - New Jersey Department of HealthSusan T. Mayne - Yale UniversityRobert Dubrow - Yale UniversityJanet L. Stanford - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaPage Abrahamson - University of North Carolina at Chapel HillHeidi Rotterdam - Columbia UniversityA. Brian West - New York UniversityJoseph F. Fraumeni - National Institutes of HealthWong-Ho Chow - Department of Health and Human Services
- Publication Details
- Clinical gastroenterology and hepatology, v 3(3), pp 225-230
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000234105000006
- Scopus ID
- 2-s2.0-20244375113
- Other Identifier
- 991020099926804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology