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Journal article
Demographic diversity of genetic databases used in Alzheimer's disease research
Human genetics
24 Apr 2023
PMID: 37093293
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
For several years, experts have warned about the lack of diversity in genetic research databases, and researchers have devoted time and resources to recruiting subjects from underrepresented subgroups. In this study, we review published reports in academic journals of genetic studies of Alzheimer's disease to note whether demographic diversity was indicated in the reports and, if so, the extent of representation of non-European subjects over the period from 1997 to 2022. We use multivariate regression analysis to analyze changes over time and to explain variation across studies. Our analysis indicates that reported diversity has not changed over time. Rather, it appears to have remained relatively constant, since Genome-Wide Association Studies (GWASs) were first used in the 1990s. We find most variation to be across journals rather than within journals, suggesting that characteristics of journals are an important influence on the dissemination of research with diverse samples. Lack of racial diversity in genetic databases used to develop clinical applications could lead to disparities in the effectiveness of those applications for underrepresented groups.
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Details
- Title
- Demographic diversity of genetic databases used in Alzheimer's disease research
- Creators
- Robert I Field - Drexel UniversityAnthony W Orlando - California State Polytechnic UniversityArnold J Rosoff - University of Pennsylvania
- Publication Details
- Human genetics
- Publisher
- Springer Nature
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Thomas R. Kline School of Law
- Web of Science ID
- WOS:000973860300002
- Scopus ID
- 2-s2.0-85153407118
- Other Identifier
- 991020440562204721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity