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Dense and Dynamic Polyethylene Glycol Shells Cloak Nanoparticles from Uptake by Liver Endothelial Cells for Long Blood Circulation
Journal article   Open access   Peer reviewed

Dense and Dynamic Polyethylene Glycol Shells Cloak Nanoparticles from Uptake by Liver Endothelial Cells for Long Blood Circulation

Hao Zhou, Zhiyuan Fan, Peter Y Li, Junjie Deng, Dimitrios C Arhontoulis, Christopher Y Li, Wilbur B Bowne and Hao Cheng
ACS nano, v 12(10), pp 10130-10141
23 Oct 2018
DOI: https://doi.org/10.1021/acsnano.8b04947
PMID: 30117736
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc6349371View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Animals Dynamic Light Scattering Endothelial Cells - chemistry Endothelial Cells - metabolism Female Liver - chemistry Liver - cytology Liver - metabolism Mice Mice, Inbred BALB C Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoparticles - metabolism Particle Size Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Polyethylene Glycols - metabolism Surface Properties
Research into long-circulating nanoparticles has in the past focused on reducing their clearance by macrophages. By engineering a hierarchical polyethylene glycol (PEG) structure on nanoparticle surfaces, we revealed an alternative mechanism to enhance nanoparticle blood circulation. The conjugation of a second PEG layer at a density close to but lower than the mushroom-to-brush transition regime on conventional PEGylated nanoparticles dramatically prolongs their blood circulation via reduced nanoparticle uptake by non-Kupffer cells in the liver, especially liver sinusoidal endothelial cells. Our study also disclosed that the dynamic outer PEG layer reduces protein binding affinity to nanoparticles, although not the total number of adsorbed proteins. These effects of the outer PEG layer diminish in the higher density regime. Therefore, our results suggest that the dynamic topographical structure of nanoparticles is an important factor in governing their fate in vivo. Taken together, this study advances our understanding of nanoparticle blood circulation and provides a facile approach for generating long circulating nanoparticles.

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184 citations in Web of Science
180 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Chemistry, Multidisciplinary
Chemistry, Physical
Materials Science, Multidisciplinary
Nanoscience & Nanotechnology
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