Journal article
Depletion of T cells by type I interferon: differences between young and aged mice
The Journal of immunology (1950), v 175(3), pp 1820-1826
01 Aug 2005
PMID: 16034124
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Abstract
Type I IFN (IFN-I or IFN-alphabeta) plays an important role in the innate immune response against viral infection. Here we report that a potent inducer of IFN-alphabeta, polyinosinic-polycytidylic acid [poly(I:C)], led to the depletion of T cells in young, but not aged mice, and that this depletion was limited to central memory, but not effector memory, T cells. Although early activation of T cells in vivo by poly(I:C), as demonstrated by CD69, was not impaired with aging, the expression of active caspase-3 was higher in young compared with aged mice. This depletion of T cells and induction of active caspase-3 in young mice and of CD69 in both young and aged mice by poly(I:C) were blocked by anti-IFN-alphabeta Ab. Although poly(I:C) stimulated lower circulating levels of IFN-alphabeta in aged mice, administration of IFN-alphabeta after poly(I:C) did not induce depletion of T cells in aged mice. These results indicate that IFN-alphabeta plays a critical role in the depletion of T cells of young mice, and further suggest that the lower level of functional IFN-alphabeta and decreased induction of active caspase-3 in T cells of aged mice after poly(I:C) may be responsible for the increased resistance of T cells of aged mice to depletion.
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Details
- Title
- Depletion of T cells by type I interferon: differences between young and aged mice
- Creators
- Jiu Jiang - Drexel UniversityDiara Gross - Drexel UniversityShoko Nogusa - Drexel UniversityPhilip Elbaum - Drexel UniversityDonna M Murasko - Drexel University
- Publication Details
- The Journal of immunology (1950), v 175(3), pp 1820-1826
- Publisher
- American Association of Immunologists (AAI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Biology
- Web of Science ID
- WOS:000233648000055
- Scopus ID
- 2-s2.0-22544457163
- Other Identifier
- 991020950530204721
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- Web of Science research areas
- Immunology