Journal article
Deposition of Beta-amyloid subtypes 40 and 42 differentiates dementia with Lewy bodies from Alzheimer disease
Archives of neurology (Chicago), v 56(9), pp 1111-1118
01 Sep 1999
PMID: 10488812
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Alterations in the metabolism of the amyloid precursor protein and the formation of beta-amyloid (Abeta) plaques are associated with neuronal death in Alzheimer disease (AD). The plaque subtype Abeta(x-42) occurs as an early event, with Abeta(x-40) plaques forming at a later stage. In dementia with Lewy bodies (DLB), an increase in the amount of cortical Abeta occurs without severe cortical neuronal losses. OBJECTIVE: To advance our understanding of the natural history of Abeta in neurodegenerative diseases. DESIGN: We evaluated the expression of Abeta(x-40) and Abeta(x-42) in DLB using monoclonal antibodies and immunohistochemical techniques in 5 brain regions. The data were compared with those elicited with normal aging and from patients with AD. SETTING AND PATIENTS: A postmortem study involving 19 patients with DLB without concurrent neuritic degeneration, 10 patients with AD, and 17 aged persons without dementia for control subjects. RESULTS: The Abeta plaques were more numerous in patients with DLB than in controls in most brain regions, although the Abeta(x-42) plaque subtype was predominant in both conditions. Overall, Abeta(x-42) plaque density was similar in patients with DLB and those with AD, but Abeta(x-40) plaques were more numerous in persons with AD than in those with DLB. The ratio of Abeta(x-40) to Abeta(x-42) plaques was significantly reduced in persons with DLB compared with patients with AD. CONCLUSIONS: The Abeta plaques were more numerous in patients with DLB than persons with normal aging, but the plaque subtypes were similar. The relative proportion of the 2 Abeta plaque subtypes in DLB is distinguishable from that in AD.
Metrics
Details
- Title
- Deposition of Beta-amyloid subtypes 40 and 42 differentiates dementia with Lewy bodies from Alzheimer disease
- Creators
- Carol Lippa - Hahnemann University HospitalKazuharu OzawaDavid MannKazuhiro Ishii
- Publication Details
- Archives of neurology (Chicago), v 56(9), pp 1111-1118
- Publisher
- American Medical Association
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000082556000009
- Scopus ID
- 2-s2.0-0032887165
- Other Identifier
- 991019312388504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology