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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Deprenyl reduces inflammation during acute SIV infection
iScience, v 25(5), 104207
20 May 2022
PMID: 35494221
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In the era of antiretroviral therapy, inflammation is a central factor in numerous HIV-associated comorbidities, such as cardiovascular disease, cognitive impairment, and neuropsychiatric disorders. This highlights the value of developing therapeutics that both reduce HIV-associated inflammation and treat associated comorbidities. Previous research on monoamine oxidase inhibitors (MAOIs) suggests this class of drugs has anti-inflammatory properties in addition to neuropsychiatric effects. Therefore, we examined the impact of deprenyl, an MAOI, on SIV-associated inflammation during acute SIV infection using the rhesus macaque model of HIV infection. Our results show deprenyl decreased both peripheral and CNS inflammation but had no effect on viral load in either the periphery or CNS. These data show that the MAOI deprenyl may have broad anti-inflammatory effects when given during the acute stage of SIV infection, suggesting more research into the anti-inflammatory effects of this drug could result in a beneficial adjuvant for antiretroviral therapy.
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•Deprenyl reduces peripheral and CNS inflammation in acute SIV infection•Acute SIV infection alters monoamine levels in CNS•Describes regional monoamine and metabolite levels in rhesus macaque brains•Details levels of inflammatory analytes in healthy rhesus macaque peripheral blood
Biological sciences; Immunology; Microbiology
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Details
- Title
- Deprenyl reduces inflammation during acute SIV infection
- Creators
- K.M. Emanuel - University of Nebraska Medical CenterK. Runner - Drexel UniversityZ.D. Brodnik - Drexel UniversityB.M. Morsey - University of Nebraska Medical CenterB.G. Lamberty - University of Nebraska Medical CenterH.S. Johnson - Drexel UniversityA. Acharya - University of Nebraska Medical CenterS.N. Byrareddy - University of Nebraska Medical CenterR.A. España - Drexel UniversityH.S. Fox - University of Nebraska Medical CenterP.J. Gaskill - Drexel University
- Publication Details
- iScience, v 25(5), 104207
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Pharmacology and Physiology
- Web of Science ID
- WOS:000794932600007
- Scopus ID
- 2-s2.0-85129122672
- Other Identifier
- 991019167948004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology