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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Depression and Apathy Among People Living with HIV: Implications for Treatment of HIV Associated Neurocognitive Disorders
AIDS and behavior, v 19(8), pp 1430-1437
01 Aug 2015
PMID: 25533921
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Depression and apathy are common among people living with HIV (PLWH). However, in PLWH, it is unclear whether depression and apathy are distinct conditions, which contribute to different patterns of disruption to cognitive processing and brain systems. Understanding these conditions may enable the development of prognostic indicators for HIV associated neurocognitive disorders (HAND). The present study examined substance use behavior and cognitive deficits, associated with depression and apathy, in 120 PLWH, using hierarchical regression analyses. Higher levels of depression were associated with a history of alcohol dependence and greater deficits in processing speed, motor and global cognitive functioning. Higher levels of apathy were associated with a history of cocaine dependence. It is recommended that PLWH get screened appropriately for apathy and depression, in order to receive the appropriate treatment, considering the comorbidities associated with each condition. Future research should examine the neurological correlates of apathy and depression in PLWH.
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Details
- Title
- Depression and Apathy Among People Living with HIV: Implications for Treatment of HIV Associated Neurocognitive Disorders
- Creators
- Vaughn E. Bryant - University of Florida Health Science CenterNicole E. Whitehead - University of Florida HealthLarry E. Burrell - University of Florida HealthVonetta M. Dotson - University of Florida HealthRobert L. Cook - University of FloridaPaul Malloy - Brown UniversityKathryn Devlin - Temple UniversityRonald A. Cohen - University of Florida Health Science Center
- Publication Details
- AIDS and behavior, v 19(8), pp 1430-1437
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- P30AG028740 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01MH074368; P01AA019072 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA KL2TR001429 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) R01MH074368 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) P30AI042853 / Lifespan/Tufts/Brown Center for AIDS Research P30AI042853 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) U24AA022002 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000359014800007
- Scopus ID
- 2-s2.0-84938740357
- Other Identifier
- 991021463584804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health
- Social Sciences, Biomedical