Journal article
Depression and type 2 diabetes mellitus: The multiethnic study of atherosclerosis
Psychosomatic medicine, v 69(6), pp 529-536
01 Jul 2007
PMID: 17636146
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To assess the cross-sectional association between depression and glucose tolerance status. Methods: We conducted a study of 6754 White, Black, Hispanic, and Chinese men and women aged 45 to 84 years in the Multiethnic Study of Atherosclerosis (MESA). Depression was defined as Center for Epidemiologic Studies Depression scale score of >= 16 and/or antidepressant use. Glucose tolerance status was defined as normal, impaired fasting glucose (IFG) or Type 2 diabetes mellitus (untreated and treated). Results: In the minimally adjusted model, although depression was not associated with a greater odds of IFG (odds ratio (OR) = 1.01; 95% confidence interval (CI): 0.87-1.18) or untreated diabetes (OR = 1.03; 95% CI: 0.74-1.45), it was associated with a greater odds of treated diabetes (OR = 1.57; 95% CI: 1.27-1.96). This persisted following adjustment for body mass index (OR 1.52; 95% CI: 1.22-1.90), metabolic (OR = 1.54; 95% CI: 1.23-1.93), and inflammatory (OR = 1.53; 95% CI: 1.21-1.92) factors, daily caloric intake and smoking (OR = 1.48; 95% CI: 1.16-1.88), and socioeconomic markers (OR = 1.47; 95% CI: 1.17-1.85). Among individuals with treated diabetes, median depression scores were higher in those with microalbuminuria compared with those without microalbuminuria (median = 7; interquartile range: 3-13 versus median = 6; interquartile range: 2-11; p = .046). Depression scores were not associated with homeostatic model assessment of insulin resistance among individuals without diabetes. Conclusions: In MESA, depression was significantly associated with treated diabetes. Further studies are needed to determine the temporality of this association.
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Details
- Title
- Depression and type 2 diabetes mellitus: The multiethnic study of atherosclerosis
- Creators
- Sherita Hill Golden - Johns Hopkins UniversityHochang Benjamin Lee - Johns Hopkins UniversityPamela J. Schreiner - Johns Hopkins UniversityAna Diez Roux - University of MichiganAnnette L. Fitzpatrick - University of WashingtonMoyses Szklo - Johns Hopkins UniversityConstantine Lyketsos - Johns Hopkins University
- Publication Details
- Psychosomatic medicine, v 69(6), pp 529-536
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- N01-HC-95169; N01-HC-95159; N01-HC-95165 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 5 K23 DK071565 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K23DK071565 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) N01HC095165 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000248535600008
- Scopus ID
- 2-s2.0-34547621403
- Other Identifier
- 991020112260404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry
- Psychology
- Psychology, Multidisciplinary