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Depression may be a risk factor for coronary heart disease in midlife women <65 years: A 9-year prospective cohort study
Journal article   Peer reviewed

Depression may be a risk factor for coronary heart disease in midlife women <65 years: A 9-year prospective cohort study

Xuezhi Jiang, Ragad Asmaro, David M. O'Sullivan, Jaymin Modi, Elizabeth Budnik and Peter F. Schnatz
International journal of cardiology, v 271
15 Nov 2018
DOI: https://doi.org/10.1016/j.ijcard.2018.05.085
PMID: 29880298
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Coronary heart disease Depression Midlife women
Depression has been suggested as a risk factor for coronary heart disease (CHD). However, whether the risk may be affected by age is unknown. We seek to assess the difference in long-term CHD risk between younger (<65) and older (≥65) women with depressive symptoms. Between June and August 2004, 1995 women presenting for routine mammography were enrolled to the primary study on breast arterial calcification. In 2005 (year 2), each woman completed a validated depression screening questionnaire. A similar questionnaire was mailed to each participant at year 4, 5, and 10 to obtain follow-up data (demographic and CHD risk factors) and record any change in CHD status. Of 1084 women who returned surveys at year 10, 998 had no history of CHD and answered depression screening questions at year 2 as well as questions about CHD events at year 10. Of 185 out of 998 (18.5%) who had positive depression screening at year 2, 24 (13.0%) developed ≥1 CHD events by year 10, which is significantly higher than the incidence of 6.5% (53/813) in control group (p < 0.001). With CHD risk factors including age adjusted in a logistic regression model, depression was the only significant predictive factor for CHD in women aged <65 (OR = 6.56, 95% CI 1.07–40.09, p = 0.042). However, in women aged ≥65, age was the only significant predictive factor for CHD. A history of depression may increase the risk of CHD over 9 years of follow-up, and more prominently in midlife women aged <65 years. •The data from a wide range of studies support depression as a risk factor for coronary heart disease (CHD).•However, it is unknown if CHD risk varies with the age at which patients develop their depressive symptoms.•We assessed the long-term risk of developing CHD in midlife (<65) and older (≥65) women with depressive symptoms.•998 midlife women who had no history of CHD at baseline were followed up for 9 years for incidence of CHD.•We concluded that a history of depression may increase the risk of CHD over 9 years of follow-up in women aged <65 years.

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
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