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Journal article
Depth-Resolved Visualization of Perifoveal Retinal Vasculature in Preterm Infants Using Handheld Optical Coherence Tomography Angiography
Translational vision science & technology, v 10(9), pp 10-10
01 Aug 2021
PMID: 34357383
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose: To establish methods to visualize depth-resolved perifoveal retinal vasculature in preterm infants using handheld optical coherence tomography angiography (OCT-A). Methods: In this exploratory study, eyes of preterm infants were imaged using an investigational noncontact, handheld swept-source OCT-A device as part of the prospective BabySTEPS infant retinal imaging study. We selected high-quality OCT-A volumes at two developmental stages for analysis. Customized MATLAB scripts were used to segment retinal layers, test offset parameters, and generate depth-resolved OCT-A slabs. The superficial (SCP), intermediate (ICP), and deep (DCP) capillary plexuses were visualized and qualitatively assessed by three image graders. Results: Six eyes from six preterm infants were included in this analysis. A three-layered perifoveal retinal vasculature was successfully visualized in all three eyes (three infants) in the 40 weeks postmenstrual age (PMA) group (one of three eyes with treated type 1 retinopathy of prematurity [ROP]). No obvious ICP or DCP was found in good-quality scans of the three eyes (three infants) in the 35 weeks PMA group (three of three eyes developed type 1 ROP). Conclusions: Custom segmentation parameters are useful to visualize perifoveal retinal vasculature in preterm infants. At term age, a three-layered capillary structure is visible in most eyes, while prior to detectable flow within the ICP and DCP, the perifoveal vasculature may be better visualized in two layers. Translational Relevance: Development of segmentation parameters for depthresolved OCT-A of perifoveal retinal vasculature in preterm infants facilitates the study of human retinal vascular development and vascular pathologies of ROP.
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Details
- Title
- Depth-Resolved Visualization of Perifoveal Retinal Vasculature in Preterm Infants Using Handheld Optical Coherence Tomography Angiography
- Creators
- Pujan R. Patel - Duke UniversityRyan Imperio - Duke UniversityChristian Viehland - Duke UniversityDu Tran-Viet - Duke UniversityStephanie J. Chiu - Duke UniversityVincent Tai - Duke UniversityJoseph A. Izatt - Duke UniversityCynthia A. Toth - Duke UniversityXi Chen - Duke UniversityBabySTEPS Grp
- Publication Details
- Translational vision science & technology, v 10(9), pp 10-10
- Publisher
- Assoc Research Vision Ophthalmology Inc
- Number of pages
- 9
- Grant note
- Stein Innovation Award (CAT) Research to Prevent Blindness Career Development Award; Research to Prevent Blindness (RPB) R01EY025009; K23EY028227 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000700367100008
- Scopus ID
- 2-s2.0-85112780689
- Other Identifier
- 991019167522304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology