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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus
Arthritis and rheumatism, v 64(8), pp 2677-2686
Aug 2012
PMID: 22553077
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria in order to improve clinical relevance, meet stringent methodology requirements, and incorporate new knowledge regarding the immunology of SLE. Methods The classification criteria were derived from a set of 702 expert-rated patient scenarios. Recursive partitioning was used to derive an initial rule that was simplified and refined based on SLICC physician consensus. The SLICC group validated the classification criteria in a new validation sample of 690 new expert-rated patient scenarios. Results Seventeen criteria were identified. In the derivation set, the SLICC classification criteria resulted in fewer misclassifications compared with the current ACR classification criteria (49 versus 70; P = 0.0082) and had greater sensitivity (94% versus 86%; P < 0.0001) and equal specificity (92% versus 93%; P = 0.39). In the validation set, the SLICC classification criteria resulted in fewer misclassifications compared with the current ACR classification criteria (62 versus 74; P = 0.24) and had greater sensitivity (97% versus 83%; P < 0.0001) but lower specificity (84% versus 96%; P < 0.0001). Conclusion The new SLICC classification criteria performed well in a large set of patient scenarios rated by experts. According to the SLICC rule for the classification of SLE, the patient must satisfy at least 4 criteria, including at least one clinical criterion and one immunologic criterion OR the patient must have biopsy-proven lupus nephritis in the presence of antinuclear antibodies or antidouble-stranded DNA antibodies.
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Details
- Title
- Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus
- Creators
- Michelle Petri - Johns Hopkins MedicineAna-Maria OrbaiGraciela S. Alarcon - University of Alabama at BirminghamCaroline Gordon - University of BirminghamJoan T. Merrill - Oklahoma Medical Research FoundationPaul R. Fortin - Université LavalIan N. Bruce - University of ManchesterDavid Isenberg - UCL, London, EnglandDaniel J. Wallace - Cedars-Sinai Medical CenterOla Nived - Lund UniversityGunnar Sturfelt - Lund UniversityRosalind Ramsey-Goldman - Northwestern UniversitySang-Cheol Bae - Hanyang UniversityJohn G. Hanly - Dalhousie UniversityJorge Sanchez-Guerrero - Dalhousie UniversityAnn Clarke - University Health NetworkCynthia Aranow - McGill University Health CentreSusan Manzi - Feinstein Institute for Medical ResearchMurray Urowitz - Allegheny General HospitalDafna Gladman - Toronto Western HospitalKenneth Kalunian - Toronto Western HospitalMelissa Costner - N Dallas Dermatol Associates, Dallas, TX USAVictoria P. Werth - College Station Medical CenterAsad Zoma - Philadelphia VA Medical CenterSasha Bernatsky - Hairmyres HospitalGuillermo Ruiz-Irastorza - McGill University Health CentreMunther A. Khamashta - University of the Basque CountrySoren Jacobsen - Copenhagen Univ Hosp, Rigshosp, Copenhagen, DenmarkJill P. Buyon - NYU, New York, NY USAPeter Maddison - New York UniversityMary Anne Dooley - Univ N Carolina, Chapel Hill, NC USARonald F. van vollenhoven - Karolinska Univ Hosp, Stockholm, SwedenEllen Ginzler - Karolinska University HospitalThomas Stoll - SUNY Downstate Health Sciences UniversityChristine Peschken - Spitäler SchaffhausenJoseph L. Jorizzo - Wake Forest UniversityJeffrey P. Callen - University of LouisvilleS. Sam Lim - Emory UniversityBarri J. Fessler - University of AlabamaMurat Inanc - Istanbul UniversityDiane L. Kamen - College Station Medical CenterAnisur Rahman - Medical University of South CarolinaKristjan Steinsson - Johns Hopkins UniversityAndrew G. Franks - NYU, New York, NY USALisa Sigler - Johns Hopkins UniversitySuhail Hameed - Johns Hopkins UniversityHong Fang - Johns Hopkins UniversityNgoc Pham - Johns Hopkins UniversityRobin Brey - Johns Hopkins UniversityMichael H. Weisman - College Station Medical CenterGerald McGwin - Cedars-Sinai Medical CenterLaurence S. Magder - University of Maryland, Baltimore
- Publication Details
- Arthritis and rheumatism, v 64(8), pp 2677-2686
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- Pfizer UCB Pharma; UCB Pharma SA Human Genome Sciences; GlaxoSmithKline UL1TR000150 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) Lupus Foundation of America R01AR043727 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) GlaxoSmithKline R01-AR-043727 / NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) LEO Pharma MSD
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000306906500028
- Scopus ID
- 2-s2.0-85090985459
- Other Identifier
- 991021934012404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology