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Describing the Weight-Reduced State: Physiology, Behavior, and Interventions
Journal article   Open access   Peer reviewed

Describing the Weight-Reduced State: Physiology, Behavior, and Interventions

Louis J Aronne, Kevin D Hall, John M Jakicic, Rudolph L Leibel, Michael R Lowe, Michael Rosenbaum and Samuel Klein
Obesity (Silver Spring, Md.), v 29 Suppl 1(1), pp S9-S24
Apr 2021
PMID: 33759395
url
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022199View
Accepted (AM)Open Access (License Unspecified) Open

Abstract

Adaptation, Physiological - physiology Appetite - physiology Body Weight Maintenance - physiology Diet Energy Metabolism - physiology Exercise - physiology Health Behavior - physiology Humans Life Style National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) - organization & administration Obesity - metabolism Obesity - therapy Thermogenesis - physiology United States Weight Loss - physiology
Although many persons with obesity can lose weight by lifestyle (diet and physical activity) therapy, successful long-term weight loss is difficult to achieve, and most people who lose weight regain their lost weight over time. The neurohormonal, physiological, and behavioral factors that promote weight recidivism are unclear and complex. The National Institute of Diabetes and Digestive and Kidney Diseases convened a workshop in June 2019, titled "The Physiology of the Weight-Reduced State," to explore the mechanisms and integrative physiology of adaptations in appetite, energy expenditure, and thermogenesis that occur in the weight-reduced state and that may oppose weight-loss maintenance. The proceedings from the first session of this workshop are presented here. Drs. Michael Rosenbaum, Kevin Hall, and Rudolph Leibel discussed the physiological factors that contribute to weight regain; Dr. Michael Lowe discussed the biobehavioral issues involved in weight-loss maintenance; Dr. John Jakicic discussed the influence of physical activity on long-term weight-loss maintenance; and Dr. Louis Aronne discussed the ability of drug therapy to maintain weight loss.

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79 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Endocrinology & Metabolism
Nutrition & Dietetics
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