Journal article
Description of the local hemodynamic environment in intracranial aneurysm wall subdivisions
International journal for numerical methods in biomedical engineering, v 40(8), e3844
Aug 2024
PMID: 38952068
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intracranial aneurysms (IAs) pose severe health risks influenced by hemodynamics. This study focuses on the intricate characterization of hemodynamic conditions within the IA walls and their influence on bleb development, aiming to enhance understanding of aneurysm stability and the risk of rupture. The methods emphasized utilizing a comprehensive dataset of 359 IAs and 213 IA blebs from 268 patients to reconstruct patient-specific vascular models, analyzing blood flow using finite element methods to solve the unsteady Navier-Stokes equations, the segmentation of aneurysm wall subregions and the hemodynamic metrics wall shear stress (WSS), its metrics, and the critical points in WSS fields were computed and analyzed across different aneurysm subregions defined by saccular, streamwise, and topographical divisions. The results revealed significant variations in these metrics, correlating distinct hemodynamic environments with wall features on the aneurysm walls, such as bleb formation. Critical findings indicated that regions with low WSS and high OSI, particularly in the body and central regions of aneurysms, are prone to conditions that promote bleb formation. Conversely, areas exposed to high WSS and positive divergence, like the aneurysm neck, inflow, and outflow regions, exhibited a different but substantial risk profile for bleb development, influenced by flow impingements and convergences. These insights highlight the complexity of aneurysm behavior, suggesting that both high and low-shear environments can contribute to aneurysm pathology through distinct mechanisms.
Metrics
Details
- Title
- Description of the local hemodynamic environment in intracranial aneurysm wall subdivisions
- Creators
- Yogesh Karnam - George Mason UniversityFernando Mut - George Mason UniversityAlexander K Yu - Allegheny General HospitalBoyle Cheng - Allegheny General HospitalSepideh Amin-Hanjani - Neurological SurgeryFady T Charbel - University of Illinois at ChicagoHenry H Woo - Donald & Barbara Zucker School of Medicine at Hofstra/NorthwellMika Niemelä - Helsinki University HospitalRiikka Tulamo - Helsinki University HospitalBehnam Rezai Jahromi - Helsinki University HospitalJuhana Frösen - Tampere UniversityYasutaka Tobe - University of PittsburghAnne M Robertson - University of PittsburghJuan R Cebral - George Mason University
- Publication Details
- International journal for numerical methods in biomedical engineering, v 40(8), e3844
- Publisher
- Wiley
- Grant note
- R01 NS121286 / NINDS NIH HHS #R01NS121286 / National Institutes of Health (NIH) #2R01NS097457 / National Institutes of Health (NIH) Travis C. Valentine Memorial Fund R01 NS097457 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery; Neurosurgery
- Web of Science ID
- WOS:001259188100001
- Scopus ID
- 2-s2.0-85197240646
- Other Identifier
- 991021930316804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Mathematical & Computational Biology
- Mathematics, Interdisciplinary Applications