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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Design, Development, and Operation of a Low-Intensity Focused Ultrasound Pulsation (LIFUP) System for Clinical Use
IEEE transactions on ultrasonics, ferroelectrics, and frequency control, v 68(1)
Jan 2021
PMID: 32746201
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Noninvasive low-intensity focused ultrasound pulsation (LIFUP) neuromodulation provides a unique approach to both investigating and treating the brain. This work describes a well-calibrated, simple-to-use ultrasound stimulation system for neuromodulation studies. It provides a single-element 650-kHz transducer design and a straightforward control mechanism, with extensive calibration and internal electronic monitoring to prevent unwanted over or under treatment. One goal of this approach is to relieve researchers of many of the details associated with developing their own exposure equipment. A unique transducer positioning system and distinctive MRI fiducial targets simplify alignment and targeting. The system design, control software, calibration, and alignment techniques are described in detail. Examples of transducer targeting and neurostimulation using the system are provided.
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Details
- Title
- Design, Development, and Operation of a Low-Intensity Focused Ultrasound Pulsation (LIFUP) System for Clinical Use
- Creators
- Mark E Schafer - Sonic Tech, Inc (United States, Lower Gwynedd)Norman M Spivak - University of California, Los AngelesAlexander S Korb - University of California, Los AngelesAlexander Bystritsky - University of California, Los Angeles
- Publication Details
- IEEE transactions on ultrasonics, ferroelectrics, and frequency control, v 68(1)
- Publisher
- IEEE
- Number of pages
- 11
- Grant note
- Brainsonix Corporation, Pacific Institute of Medical Research and Tiny Blue Dot Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000602706700006
- Scopus ID
- 2-s2.0-85098180262
- Other Identifier
- 991019176796304721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Acoustics
- Engineering, Electrical & Electronic