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Journal article
Design, Fabrication, and Evaluation of Polyglycolic Acid Modules with Canals as Tissue Elements in Cellular-Assembly Technology
Applied sciences, v 10(11), p3748
01 Jun 2020
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The aim of the present study was to design and fabricate polyglycolic acid (PGA) modules on the basis of the Raschig ring as a tissue element for bottom-top tissue engineering to increase the feasibility of cellular-assembly technology. Three types of modules, namely, cylindrical, Raschig ring, and transverse-pore modules, with different numbers and orientations of canals, were designed and fabricated by modified selective-laser-sintering (SLS) technology. These modules maintained their structure in a flowing culture environment, and degradation did not create an acidic environment, hence promoting their ability to scale up to highly functional tissue. The modules were seeded with human hepatoma Hep G2 cells and cultured for 10 days. The transverse-pore modules were found to have the highest glucose consumption, albumin production, and cell viability among the three tested modules. Our study showed that the proposed module design provided better mass transfer and possessed the required mechanical strength to enable use in the construction of large tissue.
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Details
- Title
- Design, Fabrication, and Evaluation of Polyglycolic Acid Modules with Canals as Tissue Elements in Cellular-Assembly Technology
- Creators
- Jingyuan Ji - Tsinghua Univ, Biomfg Ctr, Dept Mech Engn, Beijing 100084, Peoples R ChinaYuan Pang - Tsinghua Univ, Biomfg Ctr, Dept Mech Engn, Beijing 100084, Peoples R ChinaStephanie Sutoko - Univ Tokyo, Inst Ind Sci, Meguro Ku, Komaba 4-6-1, Tokyo 1538505, JapanYohei Horimoto - Shibaura Inst Technol, Grad Sch Engn, Minato Ku, Shibaura 3-9-14, Tokyo 1088548, JapanWei Sun - Tsinghua Univ, Biomfg Ctr, Dept Mech Engn, Beijing 100084, Peoples R ChinaToshiki Niino - Univ Tokyo, Inst Ind Sci, Meguro Ku, Komaba 4-6-1, Tokyo 1538505, JapanYasuyuki Sakai - Univ Tokyo, Grad Sch Engn, Dept Chem Syst Engn, Bunkyo Ku, Hongo 7-3-1, Tokyo 113033, Japan
- Publication Details
- Applied sciences, v 10(11), p3748
- Publisher
- Mdpi
- Number of pages
- 11
- Grant note
- 51805294 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2018YFA0703004 / National Key Research and Development Program of China 20193080045; 20197050024 / Tsinghua University Initiative Scientific Research Program B17026 / 111 Project; Ministry of Education, China - 111 Project
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000543385900085
- Scopus ID
- 2-s2.0-85086092586
- Other Identifier
- 991019167614904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Engineering, Multidisciplinary
- Materials Science, Multidisciplinary
- Physics, Applied