Journal article
Design and synthesis of N-alkyldeoxynojirimycin derivatives with improved metabolic stability as inhibitors of BVDV and Tacaribe virus
Bioorganic & medicinal chemistry letters, v 23(14), pp 4258-4262
15 Jul 2013
PMID: 23747225
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Novel N-alkyldeoxynojirimycins (NADNJs) based on our previous lead 3 were designed, synthesized and tested in metabolic assays and in virus cultures. NADNJs containing terminal tertiary benzamide, sulfonamide, urea, and oxazolidinone moieties were discovered to have improved metabolic stability compared to 3, while maintaining submicromolar EC50 against BVDV and Tacaribe virus; and low cytotoxicity.
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Details
- Title
- Design and synthesis of N-alkyldeoxynojirimycin derivatives with improved metabolic stability as inhibitors of BVDV and Tacaribe virus
- Creators
- Yanming Du - Hepatitis B FoundationHong Ye - Hepatitis B FoundationFang Guo - Drexel UniversityLijuan Wang - Drexel UniversityTina Gill - Drexel UniversityNoshena Khan - Hepatitis B FoundationAndrea Cuconati - Hepatitis B FoundationJu-Tao Guo - Drexel UniversityTimothy M Block - Drexel UniversityJinhong Chang - Drexel UniversityXiaodong Xu - Hepatitis B Foundation
- Publication Details
- Bioorganic & medicinal chemistry letters, v 23(14), pp 4258-4262
- Publisher
- Elsevier
- Grant note
- R01 AI104636 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000320704600050
- Scopus ID
- 2-s2.0-84879415298
- Other Identifier
- 991019167815204721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic