Journal article
Design and synthesis of tetrazole-based growth hormone secretagogue: The SAR studies of the O-benzyl serine side chain
Bioorganic & medicinal chemistry letters, v 18(6), pp 1825-1829
15 Mar 2008
PMID: 18295486
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The structure–activity relationship of the
O-benzyl serine side chain was investigated based on the tetrazole-based growth hormone secretagogue BMS-317180 (
2). The ortho position of the benzyl moiety was found to be favorable for introduction of substituents. A series of ortho-substituted compounds were synthesized with improved in-vitro and in-vivo activity. Among them, the biphenyl compound
2p shows twofold improvement in potency compared to its parent compound BMS-317180 (
2).
Metrics
Details
- Title
- Design and synthesis of tetrazole-based growth hormone secretagogue: The SAR studies of the O-benzyl serine side chain
- Creators
- Jun Li - Bristol-Myers Squibb (United States)Stephanie Y. Chen - Bristol-Myers Squibb (United States)Shiwei Tao - Bristol-Myers Squibb (United States)Haixia Wang - Bristol-Myers Squibb (United States)James J. Li - Bristol-Myers Squibb (United States)Steve Swartz - Bristol-Myers Squibb (United States)Christa Musial - Bristol-Myers Squibb (Germany)Andres A. Hernandez - Bristol-Myers Squibb (United States)Neil Flynn - Bristol-Myers Squibb (United States)Brian J. Murphy - Bristol-Myers Squibb (United States)Blake Beehler - Bristol-Myers Squibb (United States)Kenneth E. Dickinson - Bristol-Myers Squibb (United States)Leah Giupponi - Bristol-Myers Squibb (United States)Gary Grover - Bristol-Myers Squibb (United States)Ramakrishna Seethala - Bristol-Myers Squibb (United States)Paul Sleph - Bristol-Myers Squibb (United States)Dorothy Slusarchyk - Bristol-Myers Squibb (United States)Mujing Yan - Bristol-Myers Squibb (United States)William G. Humphreys - Bristol-Myers Squibb (United States)Hongjian Zhang - Bristol-Myers Squibb (United States)William R. Ewing - Bristol-Myers Squibb (United States)Jeffrey A. Robl - Bristol-Myers Squibb (United States)David Gordon - Bristol-Myers Squibb (United States)Joseph A. Tino - Bristol-Myers Squibb (Germany)
- Publication Details
- Bioorganic & medicinal chemistry letters, v 18(6), pp 1825-1829
- Publisher
- Elsevier
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000254180300013
- Scopus ID
- 2-s2.0-40849096341
- Other Identifier
- 991021903315104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic