Journal article
Desmopressin-Induced Improvement in Bleeding Times in Chronic Renal Failure Patients Correlates with Platelet Serotonin Uptake and ATP Release
The American journal of the medical sciences, v 300(6), pp 372-379
Dec 1990
PMID: 2264575
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hemostatic defects resulting in life-threatening hemorrhagic episodes are a common occurrence in the chronic renal failure patient. Hemorrhagic tendencies correlate best with laboratory tests of bleeding times. The identification of a specific hemostatic defect and its role in bleeding dyscrasias has yet to be elucidated. Our studies demonstrate that factor VIII coagulant activity and factor VIII related antigen (vWF:Ag) are normal or greatly elevated in uremic renal failure patients with greatly prolonged bleeding times. The multimeric state of the von Willebrand factor is also normal in these patients. The bleeding times were normalized in all 15 patients, 90 minutes post-infusion with desmopressin (DDAVP). No significant changes in factor VIII/vWF associated properties, blood cell counts, or coagulation factors were observed post-DDAVP treatment. However, a significant increase in platelet serotonin uptake (p < .025) and ATP release (p < .025) was detected after DDAVP treatment. These results indicate that DDAVP acts on the platelet membrane. This is further substantiated by the ability of DDAVP to block vasopressin-induced platelet aggregation in a dose-and time-dependent fashion. Perturbations in the movement and storage of serotonin and the release of adenosine 5’-triphosphate (ATP) in the platelets of uremic individuals are proposed to play a critical role in regulating bleeding times.
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Details
- Title
- Desmopressin-Induced Improvement in Bleeding Times in Chronic Renal Failure Patients Correlates with Platelet Serotonin Uptake and ATP Release
- Creators
- Gerald Soslau - Department of Biological Sciences, Hahnemann University, School of Medicine, Philadelphia, PennsylvaniaAllan B Schwartz - Neoplastic Diseases, Hahnemann University, School of Medicine, Philadelphia, PennsylvaniaBhaben Putatunda - Medicine, Hahnemann University, School of Medicine, Philadelphia, PennsylvaniaJohn D Conroy - Neoplastic Diseases, Hahnemann University, School of Medicine, Philadelphia, PennsylvaniaJanet Parker - Department of Biological Sciences, Hahnemann University, School of Medicine, Philadelphia, PennsylvaniaRobert F Abel - Coagulation Laboratory, Christiana Hospital, Newark, DelawareIsadore Brodsky - Neoplastic Diseases, Hahnemann University, School of Medicine, Philadelphia, Pennsylvania
- Publication Details
- The American journal of the medical sciences, v 300(6), pp 372-379
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nephrology (and Hypertension); [Retired Faculty]
- Web of Science ID
- WOS:A1990EQ35300006
- Scopus ID
- 2-s2.0-0025598376
- Other Identifier
- 991014878072104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Hematology