Journal article
Desymmetrization of difluoromethylene groups by C-F bond activation
Nature (London), v 583(7817), pp 548-553
23 Jul 2020
PMID: 32480398
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Tertiary stereogenic centres containing one fluorine atom are valuable for medicinal chemistry because they mimic common tertiary stereogenic centres containing one hydrogen atom, but they possess distinct charge distribution, lipophilicity, conformation and metabolic stability
. Although tertiary stereogenic centres containing one hydrogen atom are often set by enantioselective desymmetrization reactions at one of the two carbon-hydrogen (C-H) bonds of a methylene group, tertiary stereocentres containing fluorine have not yet been constructed by the analogous desymmetrization reaction at one of the two carbon-fluorine (C-F) bonds of a difluoromethylene group
. Fluorine atoms are similar in size to hydrogen atoms but have distinct electronic properties, causing C-F bonds to be exceptionally strong and geminal C-F bonds to strengthen one another
. Thus, exhaustive defluorination typically dominates over the selective replacement of a single C-F bond, hindering the development of the enantioselective substitution of one fluorine atom to form a stereogenic centre
. Here we report the catalytic, enantioselective activation of a single C-F bond in an allylic difluoromethylene group to provide a broad range of products containing a monofluorinated tertiary stereogenic centre. By combining a tailored chiral iridium phosphoramidite catalyst, which controls regioselectivity, chemoselectivity and enantioselectivity, with a fluorophilic activator, which assists the oxidative addition of the C-F bond, these reactions occur in high yield and selectivity. The design principles proposed in this work extend to palladium-catalysed benzylic substitution, demonstrating the generality of the approach.
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Details
- Title
- Desymmetrization of difluoromethylene groups by C-F bond activation
- Creators
- Trevor W Butcher - University of California, BerkeleyJonathan L Yang - University of California, BerkeleyWilli M Amberg - University of California, BerkeleyNicholas B Watkins - University of California, BerkeleyNatalie D Wilkinson - University of California, BerkeleyJohn F Hartwig - University of California, Berkeley
- Publication Details
- Nature (London), v 583(7817), pp 548-553
- Grant note
- S10 OD024998 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Nanomaterials Institute
- Web of Science ID
- WOS:000623845100001
- Scopus ID
- 2-s2.0-85085894694
- Other Identifier
- 991022207078304721
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- Web of Science research areas
- Chemistry, Multidisciplinary