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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Detection and Removal of Impurities in Nitric Oxide Generated from Air by Pulsed Electrical Discharge
Nitric oxide, v 60, pp 16-23
31 Aug 2016
PMID: 27592386
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Inhalation of nitric oxide (NO) produces selective pulmonary vasodilation without dilating the systemic circulation. However, the current NO/N
2
cylinder delivery system is cumbersome and expensive. We developed a lightweight, portable, and economical device to generate NO from air by pulsed electrical discharge. The objective of this study was to investigate and optimize the purity and safety of NO generated by this device. By using low temperature streamer discharges in the plasma generator, we produced therapeutic levels of NO with very low levels of nitrogen dioxide (NO
2
) and ozone. Despite the low temperature, spark generation eroded the surface of the electrodes, contaminating the gas stream with metal particles. During prolonged NO generation there was gradual loss of the iridium high-voltage tip (−90 µg/day) and the platinum-nickel ground electrode (−55 µg/day). Metal particles released from the electrodes were trapped by a high-efficiency particulate air (HEPA) filter. Quadrupole mass spectroscopy measurements of effluent gas during plasma NO generation showed that a single HEPA filter removed all of the metal particles. Mice were exposed to breathing 50 parts per million of electrically generated NO in air for 28 days with only a scavenger and no HEPA filter; the mice did not develop pulmonary inflammation or structural changes and iridium and platinum particles were not detected in the lungs of these mice. In conclusion, an electric plasma generator produced therapeutic levels of NO from air; scavenging and filtration effectively eliminated metallic impurities from the effluent gas.
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Details
- Title
- Detection and Removal of Impurities in Nitric Oxide Generated from Air by Pulsed Electrical Discharge
- Creators
- Binglan Yu - Massachusetts General HospitalAron H. Blaesi - Massachusetts General HospitalNoel Casey - Boston UniversityGrigory Raykhtsaum - Department of Metallurgy, LeachGarner, Attleboro, MA 02703, USA.Luca Zazzeron - Massachusetts General HospitalRosemary Jones - Massachusetts General HospitalAlexander Morrese - Applied Physics Laboratory, A. J. Drexel Plasma Institute, Drexel University, Camden, NJ 08103, USADanil Dobrynin - Drexel UniversityRajeev Malhotra - Massachusetts General HospitalDonald B. Bloch - Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA 02114 Center for Biometals & Metallomics, Boston University School of Medicine, College of Engineering, Photonics Center, and Alzheimer's Disease Center, Boston, Massachusetts, USA 02118 Department of Metallurgy, LeachGarner, Attleboro, MA 02703 Applied Physics Laboratory, A. J. Drexel Plasma Institute, Drexel University, Camden, NJ 08103 Cardiology Division and Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA 02114 Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA 02114Lee E. Goldstein - Boston UniversityWarren M. Zapol - Massachusetts General Hospital
- Publication Details
- Nitric oxide, v 60, pp 16-23
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- C. and J. Nyheim Plasma Institute
- Web of Science ID
- WOS:000387197000003
- Scopus ID
- 2-s2.0-84987624670
- Other Identifier
- 991019168763004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology