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Journal article
Detection of Pb2+ in Aqueous Solution by Using a DNA-modified Microcantilever
Analytical sciences, v 32(10), pp 1065-1069
01 Oct 2016
PMID: 27725605
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We developed a novel Pb2+-sensor based on a microcantilever that was modified with a specific Pb2+-dependent DNAzyme molecule. This microcantilever sensor could detect Pb2+ sensitively and selectively in an aqueous solution. Upon complexation with Pb2+, the DNAzyme duplex unwinded and formed a G-quadruplex conformation, which led to an increase of repulsion between the DNAzyme molecules and a subsequent bending of the microcantilever. This microcantilever sensor could be regenerated, flowing through a strong Pb2+ chelator, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid. The detection limit of the microcantilever sensor for Pb2+ ions is as low as 10(-8) M. The microcantilever sensor also exhibited a high selectivity to Pb2+ over other metal ions such as Mg2+, Fe+, Zn2+, Ca2+, and Cd2+.
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Details
- Title
- Detection of Pb2+ in Aqueous Solution by Using a DNA-modified Microcantilever
- Creators
- Rong-Peng Peng - Chinese Academy of SciencesLing-Bao Xing - Chinese Academy of SciencesXiao-Jun Wang - Chinese Academy of SciencesCheng-juan Wu - Chinese Academy of SciencesBin Chen - Chinese Academy of SciencesHai-Feng Ji - Drexel UniversityLi-Zhu Wu - Chinese Academy of SciencesChen-Ho Tung - Chinese Academy of Sciences
- Publication Details
- Analytical sciences, v 32(10), pp 1065-1069
- Publisher
- Japan Soc Analytical Chemistry
- Number of pages
- 5
- Grant note
- 2007CB808004; 2007CB936001; 2009CB22008 / Ministry of Science and Technology of China; Ministry of Science and Technology, China 20732007; 20920102033; 20972171 / National Science Foundation of China; National Natural Science Foundation of China (NSFC) Bureau for Basic Research of Chinese Academy of Sciences; Chinese Academy of Sciences
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000386423300006
- Scopus ID
- 2-s2.0-84992520811
- Other Identifier
- 991019173430004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Analytical