Journal article
Detection of increased amounts of the extracellular domain of the c-erbB-2 oncoprotein in serum during pulmonary carcinogenesis in humans
International journal of cancer, v 56(3), pp 383-386
01 Jan 1994
PMID: 7906254
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Over-expression of the c-erbB-2 oncogene-encoded p185 protein product has been implicated in the pathogenesis of a wide variety of human malignancies, including lung cancer. Over-expression of p185 can be detected immunologically by quantification of the extracellular domain of p185 (c-erbB-2 oncopeptide) in extracellular fluid in vitro and in serum in vivo. An enzyme-linked immunosorbent assay (ELISA) for the c-erbB-2 oncopeptide was used to examine banked serum samples of 11 pneumoconiosis patients who subsequently developed lung cancer and serum samples of 11 hospital controls matched for age, sex, ethnic group and smoking as well as 55 unmatched general population controls. The mean serum level for the c-erbB-2 oncopeptide in human neu units/ml in the lung cancer cases (1,756 plus or minus 549 HNU/ml) was statistically significantly elevated (p < 0.001) in comparison to the mean level in the matched controls (976 plus or minus 488 HNU/ml) or the general population controls (888 plus or minus 655 HNU/ml). Defining a positive elevation of the serum c-erbB-2 oncopeptide as any value more than 2 standard deviations above the mean of the matched controls, 64% (7 of 11) of the lung cancer cases were positive compared to O% (0 of 11) matched controls and 5% (3 of 55) of the unmatched controls. In addition, 4 of the 7 c-erbB-2 oncopeptide-positive cancer cases had positive serum samples prior to the time of disease diagnosis (average = 35 months). These results suggest that serum c-erbB-2 oncopeptide may be elevated at an early stage of pulmonary carcinogenesis and that further prospective study of the utility of this biomarker is warranted.
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Details
- Title
- Detection of increased amounts of the extracellular domain of the c-erbB-2 oncoprotein in serum during pulmonary carcinogenesis in humans
- Creators
- P Brandt-Rauf - Columbia UniversityJiin-Chyuan LuoW Carney - Oncogene ScienceS Smith - Columbia UniversityI DeVivo - Columbia UniversityC Milling - Columbia UniversityK Hemminki - Karolinska InstitutetH Koskinen - Finnish Institute of Occupational HealthH Vainio - Finnish Institute of Occupational HealthA I Neugut - Columbia University
- Publication Details
- International journal of cancer, v 56(3), pp 383-386
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1994MU55600015
- Scopus ID
- 2-s2.0-0028222828
- Other Identifier
- 991019342583904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology