Journal article
Detection of non-CLL-like monoclonal B cell lymphocytosis increases dramatically in the very elderly, while detection of CLL-like populations varies by race: findings in a multiethnic population-based cohort of elderly women
Annals of hematology, v 95(10), pp 1695-1704
Oct 2016
PMID: 27468854
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Monoclonal B cell lymphocytosis (MBL) is both a marker of immune senescence and a potential precursor of B cell malignancy. Most MBL populations have a chronic lymphocytic leukemia-like (CLL-like) immunophenotype, but those that are CD5-negative (non-CLL-like) are also recognized and may represent a distinct diagnostic entity. To date, MBL studies have taken place in relatively homogenous populations, although risk of CLL varies across racial groups and geographic regions. We report flow cytometry data from 597 ethnically diverse 64-94-year-old women from across the USA who are participants in the Women's Health Initiative (WHI) Long-Life Study (LLS). Overall, MBL was detected in 26 % of the participants and included 20.9 % with a CLL-like immunophenotype, 5 % with a non-CLL-like immunophenotype, and 1.3 % with both. White and Hispanic women were more than twice as likely to have a CLL-like MBL population detected than African American women, corrected for age (P = 0.003). By contrast, detection of non-CLL-like MBL did not vary significantly by race, but did increase markedly with advancing age, being present in 12.7 % of those aged 85 and older. We provide new evidence that rates of detection of CLL-like MBL are lower in African Americans, and further suggest that non-CLL-like clonal expansions should be regarded as distinct from CLL-like MBL.
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Details
- Title
- Detection of non-CLL-like monoclonal B cell lymphocytosis increases dramatically in the very elderly, while detection of CLL-like populations varies by race: findings in a multiethnic population-based cohort of elderly women
- Creators
- Kerstin L Edlefsen - University of Washington Medical CenterSindhu Cherian - University of Washington Medical CenterAnneclaire J De Roos - Drexel UniversityAsqual Getaneh - MedStar HealthLawrence Lessin - Washington Cancer Institute at Medstar Washington Hospital CenterWenjun Li - University of Massachusetts Medical SchoolBrent L Wood - University of Washington Medical CenterAlexander P Reiner - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
- Publication Details
- Annals of hematology, v 95(10), pp 1695-1704
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000387352800014
- Scopus ID
- 2-s2.0-84979979899
- Other Identifier
- 991019169677004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology