Journal article
Detection of prohibited substances in equestrian sport through direct injection of equine serum using micellar LC
Bioanalysis, v 2(2)
Feb 2010
PMID: 21083306
Abstract
Detection of prohibited substances in equestrian sports typically involves time-consuming and tedious sample-preparation methods. Micellar LC (MLC) allows for direct injection of equine serum to detect prohibited NSAIDs.
The method was linear over the range of standards examined, with recoveries of 94.2-95.1% for phenylbutazone (12-18 µg/ml), and 83.9-88.7% and 87.9-105.0% for diclofenac and flunixin, respectively (0.1-1.2 µg/ml). The limit of detection was 0.1 µg/ml for all compounds and the limit of quantitation was 0.2 µg/ml for phenylbutazone and 0.3 µg/ml for diclofenac and flunixin.
The MLC method of direct equine serum injection was shown to be valid and simple for the quantitation of banned NSAIDs in equine serum.
Metrics
Details
- Title
- Detection of prohibited substances in equestrian sport through direct injection of equine serum using micellar LC
- Creators
- David P Thomas - Analytical Operations, GPSG, A Division of Ortho-McNeil-Janssen Pharmaceuticals Inc., 1125 Trenton-Harbourton Road, Titusville, NJ 08560, USA. dthoma12@its.jnj.comJoe P Foley
- Publication Details
- Bioanalysis, v 2(2)
- Publisher
- England
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000281410200017
- Scopus ID
- 2-s2.0-79952514360
- Other Identifier
- 991014877681804721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemical Research Methods
- Chemistry, Analytical