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Detection of urine DNA markers for monitoring recurrent hepatocellular carcinoma
Journal article   Open access

Detection of urine DNA markers for monitoring recurrent hepatocellular carcinoma

Hie-Won Hann, Surbhi Jain, Grace Park, Jamin D Steffen, Wei Song and Ying-Hsiu Su
Hepatoma research, v 3(6), pp 105-111
01 Jan 2017
DOI: https://doi.org/10.20517/2394-5079.2017.15
PMID: 28795155
url
https://doi.org/10.20517/2394-5079.2017.15View
Published, Version of Record (VoR) Open

Abstract

recurrence hepatitis B virus urine tumor marker Hepatocellular carcinoma circulating-tumor DNA liver cancer biomarker
This study aimed to explore the potential of detecting hepatocellular carcinoma (HCC)-associated DNA markers, mutations and aberrant methylation of and genes, for monitoring HCC recurrence. HCC remains a leading cause of death worldwide, with one of the fastest growing incidence rates in the US. While treatment options are available and new ones emerging, there remains a poor prognosis of this disease mostly due to its late diagnosis and high recurrence rate. Although there are no specific guidelines addressing how HCC recurrence should be monitored, recurrence is usually monitored by serum-alpha fetal protein and imaging methods such as magnetic resonance imaging (MRI). However, early detection of recurrent HCC remains limited, particularly at the site of treated lesion. Here, the authors followed 10 patients that were treated for a primary HCC, and monitored for months or years later. At these follow-up visits, urine was collected and tested retrospectively for 3 DNA biomarkers that associate with HCC development. This 10-patient study compared detection of urine DNA markers with MRI for monitoring HCC recurrence. Five patients were confirmed by MRI for recurrence, and all 5 had detectable DNA biomarkers up to 9 months before recurrence confirmation by MRI. Overall, this suggests that detection of HCC-associated DNA markers in urine could provide a promising tool to complement detection of recurrent HCC by imaging.

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