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Journal article
Determinants of SARS-CoV-2 IgG response and decay in Canadian healthcare workers: A prospective cohort study
Vaccine, Vol.42(5), pp.1168-1178
15 Feb 2024
PMID: 38278628
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Healthcare workers (HCWs) from an interprovincial Canadian cohort gave serial blood samples to identify factors associated with anti-receptor binding domain (anti-RBD) IgG response to the SARS-CoV-2 virus.
Members of the HCW cohort donated blood samples four months after their first SARS-CoV-2 immunization and again at 7, 10 and 13 months. Date and type of immunizations and dates of SARS-CoV-2 infection were collected at each of four contacts, together with information on immunologically-compromising conditions and current therapies. Blood samples were analyzed centrally for anti-RBD IgG and anti-nucleocapsid IgG (Abbott Architect, Abbott Diagnostics). Records of immunization and SARS-CoV-2 testing from public health agencies were used to assess the impact of reporting errors on estimates from the random-effects multivariable model fitted to the data.
2752 of 4567 vaccinated cohort participants agreed to donate at least one blood sample. Modelling of anti-RBD IgG titer from 8903 samples showed an increase in IgG with each vaccine dose and with first infection. A decrease in IgG titer was found with the number of months since vaccination or infection, with the sharpest decline after the third dose. An immunization regime that included mRNA1273 (Moderna) resulted in higher anti-RBD IgG. Participants reporting multiple sclerosis, rheumatoid arthritis or taking selective immunosuppressants, tumor necrosis factor inhibitors, calcineurin inhibitors and antineoplastic agents had lower anti-RBD IgG. Supplementary analyses showed higher anti-RBD IgG in those reporting side-effects of vaccination, no relation of anti-RBD IgG to obesity and lower titers in women immunized in early or mid-pregnancy. Sensitivity analysis results suggested no important bias in the self-report data.
Creation of a prospective cohort was central to the credibility of results presented here. Serial serology assessments, with longitudinal analysis, provided effect estimates with enhanced accuracy and a clearer understanding of medical and other factors affecting response to vaccination.
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Details
- Title
- Determinants of SARS-CoV-2 IgG response and decay in Canadian healthcare workers: A prospective cohort study
- Creators
- Nicola Cherry - University of AlbertaAnil Adisesh - University of TorontoIgor Burstyn - Drexel University, Environmental and Occupational HealthCarmen Charlton - Alberta Precision Laboratories, 84440 112 St, Edmonton, AB T6G 2I2, CanadaYan Chen - St. Jude Children's Research HospitalQuentin Durand-Moreau - University of AlbertaFrance Labrèche - Institut de Recherche Robert-Sauvé en Santé et en Sécurité du TravailShannon Ruzycki - University of CalgaryLeeAnn Turnbull - Alberta Precision Laboratories, 84440 112 St, Edmonton, AB T6G 2I2, CanadaTanis Zadunayski - University of AlbertaYutaka Yasui - Department of Epidemiology & Cancer Control, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Mail Stop 735, Memphis, TN 38105, USA
- Publication Details
- Vaccine, Vol.42(5), pp.1168-1178
- Publisher
- Elsevier
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Identifiers
- 991022019814504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental