Journal article
Determinants of fatal apnea responses to acid stimulation of the larynx in piglets
Annals of otology, rhinology & laryngology, v 114(7), pp 509-516
01 Jul 2005
PMID: 16134345
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study explores the physiological determinants of laryngeal chemoreflex (LCR) response severity under hypoxic conditions.
Thirty-four piglets underwent hypoxic laryngeal stimulation. Physiologic data were collected, and responses were graded as mild, moderate, or profound.
Prestimulation hypoxia caused respiratory depression and carbon dioxide retention in profound responders and respiratory stimulation in mild and moderate responders (p < .05). Resumption of respiration occurred in all animals when the PaCO2 rose by a mean +/- SD of 15.1 +/- 6.5 mm Hg (p > .05). There was a significant difference between mild, moderate, and severe responders in change in arterial PaO2 and hydrogenated hemoglobin saturation during the LCR-induced response (p < .001 for both).
Resumption of respiration is associated with accumulation of arterial PaCO2. The respiratory response to hypoxia predicts the severity of the LCR response. The severity of the LCR-induced response is associated with changes in arterial PaO2 and hydrogenated hemoglobin saturation during the LCR-induced apnea.
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Details
- Title
- Determinants of fatal apnea responses to acid stimulation of the larynx in piglets
- Creators
- Yolanda D Heman-Ackah - University of Illinois at Chicago
- Publication Details
- Annals of otology, rhinology & laryngology, v 114(7), pp 509-516
- Publisher
- Sage
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:000230570900003
- Scopus ID
- 2-s2.0-22244465202
- Other Identifier
- 991021931776004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Otorhinolaryngology