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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Determinants of minimal elevation in high-sensitivity cardiac troponin T in the general population
Clinical biochemistry, v 49(9), pp 657-662
01 Jun 2016
PMID: 26975902
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To study the relationship between cardiovascular risk factors and detectable cardiac troponin-T using a highly sensitive assay (hs-cTnT) among persons without a history of cardiovascular disease.
We examined the cross-sectional associations between cardiovascular risk factors and hs-cTnT in 9593 participants (mean age 65.6 (SD, 5.6), 41% female, 22% black) free of cardiovascular disease in a community-based cohort, through the Atherosclerosis Risk in Communities (ARIC) Study. We used multivariable logistic regression to characterize the association between cardiovascular risk factors and detectable (≥3.0 to 13.9ng/L) and elevated (≥14.0ng/L) hs-cTnT.
hs-cTnT was detectable in 59% and elevated in 7% of the study population. Among persons with ideal cardiovascular health, hs-cTnT was detectable in 44%. In models adjusting for significant determinants of hs-cTnT concentration, detectable hs-cTnT was more frequent among males, blacks and persons with diabetes and hypertension and less frequent among statin users, current smokers and drinkers. Other risk factors associated with detectable hs-cTnT were older age, lower kidney function and higher body mass index. These risk factors were associated with elevated hs-cTnT in a similar pattern.
In a community-based sample without cardiovascular disease hs-cTnT is detectable in most adults, even among those with ideal cardiovascular health. Although most traditional cardiovascular risk factors were significant determinants of detectable and elevated hs-cTnT, the associations were particularly robust for sex, age, race, hypertension and diabetes.
•Using a high sensitivity assay cardiac troponin T is detectable in 66% of the population.•Male sex and diabetes were strongly associated with hs-cTnT.•44% of individuals with ideal cardiovascular health had detectable hs-cTnT.
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Details
- Title
- Determinants of minimal elevation in high-sensitivity cardiac troponin T in the general population
- Creators
- Jonathan Rubin - Johns Hopkins HospitalKunihiro Matsushita - Bloomberg (United States)Mariana Lazo - Bloomberg (United States)Christie M. Ballantyne - Baylor College of MedicineVijay Nambi - Michael E. DeBakey VA Medical CenterRon Hoogeveen - Baylor College of MedicineA. Richey Sharrett - Bloomberg (United States)Roger S. Blumenthal - Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, USA.Josef Coresh - Bloomberg (United States)Elizabeth Selvin - Bloomberg (United States)
- Publication Details
- Clinical biochemistry, v 49(9), pp 657-662
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000377030600004
- Scopus ID
- 2-s2.0-84962019999
- Other Identifier
- 991020550346304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medical Laboratory Technology