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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Determinants of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in house dust samples from four areas of the United States
The Science of the total environment, v 433, pp 516-522
01 Sep 2012
PMID: 22832089
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Determinants of levels of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/F) in dust in U.S. homes are not well characterized. We conducted a pilot study to evaluate the relationship between concentrations of PCDD/F in house dust and residential proximity to known sources, including industrial facilities and traffic. Samples from vacuum bag dust from homes of 40 residents of Detroit, Los Angeles, Seattle, or Iowa who participated in a population-based case-control study of non-Hodgkin lymphoma conducted in 1998-2000 were analyzed using high resolution gas chromatography/high resolution mass spectrometry for 7 PCDD and 10 PCDF congeners considered toxic by the U.S. Environmental Protection Agency (EPA). Locations of 10 types of PCDD/F-emitting facilities were obtained from the EPA; however only 4 types were located near study homes (non-hazardous waste cement kilns, coal-fired power plants, sewage sludge incinerators, and medical waste incinerators). Relationships between concentrations of each PCDD/F and proximity to industrial facilities, freight routes, and major roads were evaluated using separate multivariate regression models for each congener. The median (inter-quartile range [IQR]) toxic equivalence (TEQ) concentration of these congeners in the house dust was 20.3 pg/g (IQR=14.3, 32.7). Homes within 3 or 5 km of a cement kiln had 2 to 9-fold higher concentrations of 5 PCDD and 5 PCDF (p<0.1 in each model). Proximity to freight routes and major roads was associated with elevated concentrations of 1 PCDD and 8 PCDF. Higher concentrations of certain PCDD/F in homes near cement kilns, freight routes, and major roads suggest that these outdoor sources are contributing to indoor environmental exposures. Further study of the contribution of these sources and other facility types to total PCDD/F exposure in a larger number of homes is warranted.
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Details
- Title
- Determinants of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in house dust samples from four areas of the United States
- Creators
- N C Deziel - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, United StatesJ R Nuckols - Colorado State UniversityJ S Colt - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, United StatesA J De Roos - University of WashingtonA Pronk - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, United StatesC Gourley - Southwest Research InstituteR K Severson - The Barbara Ann Karmanos Cancer InstituteW Cozen - University of Southern CaliforniaJ R Cerhan - Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, United StatesP Hartge - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, United StatesM H Ward - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, United States
- Publication Details
- The Science of the total environment, v 433, pp 516-522
- Publisher
- Elsevier
- Grant note
- N01-CN-67008 / NCI NIH HHS N01 PC067010 / NCI NIH HHS Intramural NIH HHS N01-PC-67009 / NCI NIH HHS N01 PC065064 / WHI NIH HHS N01 PC067008 / NCI NIH HHS N01-CN-67010 / NCI NIH HHS N01 PC067009-025 / NCI NIH HHS N01 PC067009 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000308787500056
- Scopus ID
- 2-s2.0-84864051965
- Other Identifier
- 991020112080604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences