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Determination of immunoglobulin A against Gardnerella vaginalis hemolysin, sialidase, and prolidase activities in vaginal fluid: implications for adverse pregnancy outcomes
Journal article   Open access   Peer reviewed

Determination of immunoglobulin A against Gardnerella vaginalis hemolysin, sialidase, and prolidase activities in vaginal fluid: implications for adverse pregnancy outcomes

Sabina Cauci, Poul Thorsen, Diana E Schendel, Annie Bremmelgaard, Franco Quadrifoglio and Secondo Guaschino
Journal of clinical microbiology, v 41(1), pp 435-438
Jan 2003
PMID: 12517887
url
https://doi.org/10.1128/JCM.41.1.435-438.2003View
Published, Version of Record (VoR) Open

Abstract

Adult Antigens, Bacterial - analysis Dipeptidases - analysis Female Gardnerella vaginalis - chemistry Gardnerella vaginalis - enzymology Gardnerella vaginalis - immunology Gardnerella vaginalis - isolation & purification Hemolysin Proteins - analysis Humans Immunoglobulin A - immunology Neuraminidase - analysis Pregnancy Pregnancy Complications - microbiology Pregnancy Outcome Vaginosis, Bacterial - microbiology
A nested case-control study of low birth weight and preterm delivery was performed with singleton women. Immunoglobulin A (IgA) against the Gardnerella vaginalis hemolysin (anti-Gvh IgA) and sialidase and prolidase activities were determined in vaginal fluid at 17 weeks of gestation. Sialidase positivity and bacterial vaginosis with high prolidase activity were associated with 2- and 11-fold increased risks for low birth weight, respectively. No woman with bacterial vaginosis plus a strong anti-Gvh IgA response had an adverse outcome.

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Microbiology
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