Journal article
Detrusor contractility to parasympathetic mediators is differentially altered in the compensated and decompensated states of diabetic bladder dysfunction
American journal of physiology. Renal physiology, v 317(2), pp F388-F398
01 Aug 2019
PMID: 31141399
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Diabetic bladder dysfunction (DBD) affects up to 50% of all patients with diabetes, characterized by symptoms of both overactive and underactive bladder. Although most diabetic bladder dysfunction studies have been performed using models with type 1 diabetes, few have been performed in models of type 2 diabetes, which accounts for ~90% of all diabetic cases. In a type 2 rat model using a high-fat diet (HFD) and two low doses of streptozotocin (STZ), we examined voiding measurements and functional experiments in urothelium-denuded bladder strips to establish a timeline of disease progression. We hypothesized that overactive bladder symptoms (compensated state) would develop and progress into symptoms characterized by underactive bladder (decompensated state). Our results indicated that this model developed the compensated state at 1 wk after STZ and the decompensated state at 4 mo after STZ administration. Diabetic bladders were hypertrophied compared with control bladders. Increased volume per void and detrusor muscle contractility to exogenous addition of carbachol and ATP confirmed the development of the compensated state. This enhanced contractility to carbachol was not due to increased levels of M
receptor expression. Decompensation was characterized by increased volume per void, number of voids, and contractility to ATP but not carbachol. Thus, progression from the compensated to decompensated state may involve decreased contractility to muscarinic stimulation. These data suggest that the compensated state of DBD progresses temporally into the decompensated state in the male HFD/STZ model of diabetes; therefore, this male HFD/STZ model can be used to study the progression of DBD.
Metrics
Details
- Title
- Detrusor contractility to parasympathetic mediators is differentially altered in the compensated and decompensated states of diabetic bladder dysfunction
- Creators
- Nicole S Klee - Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PennsylvaniaRobert S Moreland - Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PennsylvaniaDerek M Kendig - Loyola University Maryland
- Publication Details
- American journal of physiology. Renal physiology, v 317(2), pp F388-F398
- Publisher
- American Physiological Society (APS)
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000481592600015
- Scopus ID
- 2-s2.0-85070540939
- Other Identifier
- 991021860795404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Physiology
- Urology & Nephrology