Journal article
Development and Application of a Lifestyle Score for Prevention of Lethal Prostate Cancer
JNCI : Journal of the National Cancer Institute, v 108(3), pp djv329-djv329
01 Mar 2016
PMID: 26577654
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Several lifestyle factors have been associated with risk of lethal prostate cancer, but little is known about their combined effect. Our objective was to develop and apply a lifestyle score for prevention of lethal prostate cancer.
We developed a lifestyle score among 42 701 men in the Health Professionals Follow-up Study (HPFS) followed from 1986 to 2010 and applied it among 20 324 men in the Physicians' Health Study (PHS) followed from 1982 to 2010. One point was given for each of: not currently smoking or quit 10 or more years ago, body mass index under 30 kg/m(2), high vigorous physical activity, high intake of tomatoes and fatty fish, and low intake of processed meat. Diet-only scores (range = 0-3) and total scores (range = 0-6) were calculated. We used multivariable Cox proportional hazards regression to estimate the risk of lethal prostate cancer, adjusting for potential risk factors of lethal prostate cancer. All statistical tests were two-sided.
We observed 576 lethal prostate cancer events in HPFS and 337 in PHS. Men with 5-6 vs 0-1 points had a 68% decreased risk of lethal prostate cancer (hazard ratio [HR] = 0.32, 95% confidence interval [CI] = 0.19 to 0.52) in HPFS and a non-statistically significant 38% decreased risk (HR = 0.62, 95% CI = 0.30 to 1.26) in PHS. For dietary factors only, men with 3 vs 0 points had a 46% decreased risk (HR = 0.54, 95% CI = 0.30 to 0.96) in the HPFS and a non-statistically significant 30% decreased risk (HR = 0.70, 95% CI = 0.40 to 1.23) in PHS.
Adhering to a healthy lifestyle, defined by not smoking, normal body weight, high physical activity, and a healthy diet, may lower risk of lethal prostate cancer.
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Details
- Title
- Development and Application of a Lifestyle Score for Prevention of Lethal Prostate Cancer
- Creators
- Stacey A Kenfield - University of California, San FranciscoJulie L Batista - University of California, San FranciscoJaquelyn L Jahn - Harvard UniversityMary Kathryn Downer - University of California, San FranciscoErin L Van Blarigan - University of California, San FranciscoHoward D Sesso - University of California, San FranciscoEdward L Giovannucci - Brigham and Women's HospitalMeir J Stampfer - Brigham and Women's HospitalJune M Chan - University of California, San Francisco
- Publication Details
- JNCI : Journal of the National Cancer Institute, v 108(3), pp djv329-djv329
- Publisher
- Oxford University Press
- Grant note
- UM1 CA167552 / NCI NIH HHS CA09001 / NCI NIH HHS CA40360 / NCI NIH HHS R01 CA040360 / NCI NIH HHS CA055075 / NCI NIH HHS P01 CA087969 / NCI NIH HHS R01 CA141298 / NCI NIH HHS R01 CA097193 / NCI NIH HHS CA167552 / NCI NIH HHS P01 CA055075 / NCI NIH HHS CA097193 / NCI NIH HHS T32 CA009001 / NCI NIH HHS CA131945 / NCI NIH HHS CA141298 / NCI NIH HHS R01 CA133891 / NCI NIH HHS CA133891 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000372589400001
- Scopus ID
- 2-s2.0-84962586957
- Other Identifier
- 991021448165604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology