Journal article
Development and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation
Sensors (Basel, Switzerland), v 21(22), p7581
15 Nov 2021
PMID: 34833660
Abstract
Advancements in electrode technologies to both stimulate and record the central nervous system's electrical activities are enabling significant improvements in both the understanding and treatment of different neurological diseases. However, the current neural recording and stimulating electrodes are metallic, requiring invasive and damaging methods to interface with neural tissue. These electrodes may also degrade, resulting in additional invasive procedures. Furthermore, metal electrodes may cause nerve damage due to their inherent rigidity. This paper demonstrates that novel electrically conductive organic fibers (ECFs) can be used for direct nerve stimulation. The ECFs were prepared using a standard polyester material as the structural base, with a carbon nanotube ink applied to the surface as the electrical conductor. We report on three experiments: the first one to characterize the conductive properties of the ECFs; the second one to investigate the fiber cytotoxic properties in vitro; and the third one to demonstrate the utility of the ECF for direct nerve stimulation in an in vivo rodent model.
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Details
- Title
- Development and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation
- Creators
- Bertram Richter - Allegheny Health NetworkZachary Mace - Computational Diagnostics (United States)Megan E Hays - Oklahoma State UniversitySantosh Adhikari - Oklahoma State UniversityHuy Q Pham - North Dakota State UniversityRobert J Sclabassi - Allegheny Health NetworkBenedict Kolber - The University of Texas at DallasSaigopalakrishna S Yerneni - Carnegie Mellon UniversityPhil Campbell - Carnegie Mellon UniversityBoyle Cheng - Allegheny Health NetworkNestor Tomycz - Allegheny Health NetworkDonald M Whiting - Allegheny Health NetworkTrung Q Le - North Dakota State UniversityToby L Nelson - Oklahoma State UniversitySaadyah Averick - Allegheny Health Network
- Publication Details
- Sensors (Basel, Switzerland), v 21(22), p7581
- Publisher
- MDPI
- Grant note
- U54 GM128729 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration; Surgery; Neurosurgery
- Web of Science ID
- WOS:000726913100001
- Scopus ID
- 2-s2.0-85118944134
- Other Identifier
- 991021448039304721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Analytical
- Engineering, Electrical & Electronic
- Instruments & Instrumentation