Journal article
Development and Validation of an Abridged Version of the REVEAL 2.0 Risk Score Calculator, REVEAL Lite 2, for Use in Patients With Pulmonary Arterial Hypertension
Chest, v 159(1), pp 337-346
01 Jan 2021
PMID: 32882243
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Achievement of low-risk status is a treatment goal in pulmonary arterial hypertension (PAH). Risk assessment often is performed using multiparameter tools, such as the Registry to Evaluate Early and Long-Term PAH Disease Management (REVEAL) risk calculator. Risk calculators that assess fewer variables without compromising validity may expedite risk assessment in the routine clinic setting. We describe the development and validation of REVEAL Lite 2, an abridged version of REVEAL 2.0.
Can a simplified version of the REVEAL 2.0 risk assessment calculator for patients with PAH be developed and validated?
REVEAL Lite 2 includes six noninvasive variables—functional class (FC), vital signs (systolic BP [SBP] and heart rate), 6-min walk distance (6MWD), brain natriuretic peptide (BNP)/N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and renal insufficiency (by estimated glomerular filtration rate [eGFR])—and was validated in a series of analyses (Kaplan-Meier, concordance index, Cox proportional hazard model, and multivariate analysis).
REVEAL Lite 2 approximates REVEAL 2.0 at discriminating low, intermediate, and high risk for 1-year mortality in patients in the REVEAL registry. The model indicated that the most highly predictive REVEAL Lite 2 parameter was BNP/NT-proBNP, followed by 6MWD and FC. Even if multiple, less predictive variables (heart rate, SBP, eGFR) were missing, REVEAL Lite 2 still discriminated among risk groups.
REVEAL Lite 2, an abridged version of REVEAL 2.0, provides a simplified method of risk assessment that can be implemented routinely in daily clinical practice. REVEAL Lite 2 is a robust tool that provides discrimination among patients at low, intermediate, and high risk of 1-year mortality.
ClinicalTrials.gov; No.: NCT00370214; URL: www.clinicaltrials.gov;
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Details
- Title
- Development and Validation of an Abridged Version of the REVEAL 2.0 Risk Score Calculator, REVEAL Lite 2, for Use in Patients With Pulmonary Arterial Hypertension
- Creators
- Raymond L. Benza - The Ohio State UniversityManreet K. Kanwar - Allegheny General HospitalAmresh Raina - Allegheny General HospitalJacqueline V. Scott - Carnegie Mellon UniversityCarol L. Zhao - JanssenMona Selej - JanssenC. Greg Elliott - University of UtahHarrison W. Farber - Tufts Medical Center
- Publication Details
- Chest, v 159(1), pp 337-346
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- National Institutes of Health (https://doi.org/10.13039/100000002) National Heart, Lung, and Blood Institute (https://doi.org/10.13039/100000050) Janssen Pharmaceuticals (https://doi.org/10.13039/100008897)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiology
- Web of Science ID
- WOS:000607460700062
- Scopus ID
- 2-s2.0-85099721277
- Other Identifier
- 991021932191604721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Critical Care Medicine
- Respiratory System