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Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia
Journal of Biomedical Optics, v 11(6), pp 064022-064028
28 Nov 2006
PMID: 17212545
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Detection of cerebral hypoxia-ischemia in infants remains problematic, as current monitors in clinical practice are impractical, insensitive, or nonspecific. Our study develops a multiwavelength spatial domain construct for near-infrared spectroscopy (NIRS) to detect cerebral hypoxia-ischemia and evaluates the construct in several models. The NIRS probe contains photodiode detectors 2, 3, and
from a three-wavelength, light-emitting diode. A construct determines cerebral
saturation based on spatial domain principles. Device performance and construct validity are examined in
models simulating the brain, and in piglets subjected to hypoxia, hypoxia-ischemia, and hyperoxic conditions using a weighted average of arterial and cerebral venous
saturation measured by
-oximetry. The results in the brain models verify key equations in the construct and demonstrate reliable performance of the device. In piglets, the device measures cerebral
saturation with bias
and precision
. In conclusion, this NIRS device accurately detects cerebral hypoxia-ischemia and is of a design that is practical for clinical application.
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Details
- Title
- Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia
- Creators
- Lindsey A Nelson - Cincinnati Children's Hospital Medical CenterJohn C McCann - Cincinnati Children's Hospital Medical CenterAndres W Loepke - Cincinnati Children's Hospital Medical CenterJun Wu - Cincinnati Children's Hospital Medical CenterBaruch Ben Dor - Near Infrared Monitoring Incorporated, Philadelphia, Pennsylvania 19104C. Dean Kurth - Cincinnati Children's Hospital Medical Center
- Publication Details
- Journal of Biomedical Optics, v 11(6), pp 064022-064028
- Publisher
- Society of Photo-Optical Instrumentation Engineers (SPIE)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000243968700025
- Scopus ID
- 2-s2.0-33847271586
- Other Identifier
- 991019356341604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods
- Optics
- Radiology, Nuclear Medicine & Medical Imaging