Journal article
Development of Inflammatory Bowel Disease in HIV Patients: A Danish Cohort Study (1983–2018) With American Validation (1999–2018)
Gastro hep advances, v 1(6), pp 1114-1121
2022
PMID: 36531445
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human immunodeficiency virus (HIV) infection is associated with several immune-mediated disorders. However, the risk of inflammatory bowel disease (IBD) in people living with HIV (PLWH) remains unclear. We aimed to assess the risk of IBD among PLWH using a nationwide, population-based Danish cohort and to validate findings in a large American insurance-based database.
Using Danish registries (1983–2018), we identified 8995 PLWH and age- and sex-matched them to 449,750 HIV-negative individuals. Cox regression analysis was undertaken to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) for IBD diagnosis. Results were stratified by sex, age, and year of HIV diagnosis. Using an American insurance-based cohort, Explorys (1999–2018), we assessed the prevalence odds ratio (OR) and 95% CI of IBD diagnosis in PLWH compared with HIV-negative individuals.
IBD diagnosis among PLWH in Denmark was increased (HR: 2.25, 95% CI: 1.78–2.83) compared with matched HIV-negative individuals. This was seen for both Crohn’s disease (HR: 2.25, 95% CI: 1.47–3.44) and ulcerative colitis (HR: 2.24, 95% CI: 1.70–2.96) and in male (HR: 2.75, 95% CI: 2.15–3.52) but not female (HR: 0.93, 95% CI: 0.48–1.79) PLWH. Explorys analysis also showed an increased odds of IBD diagnoses among PLWH (OR: 1.41; 95% CI: 1.35–1.49).
This study finds an increased risk of IBD diagnosis among PLWH in both a Danish and US cohort, highlighting a need to consider IBD in PLWH with new-onset gastrointestinal symptoms. Further research into the role of antiretroviral therapy in this relationship is required.
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Details
- Title
- Development of Inflammatory Bowel Disease in HIV Patients: A Danish Cohort Study (1983–2018) With American Validation (1999–2018)
- Creators
- Rahma Elmahdi - Aalborg UniversityGursimran S. Kochhar - Allegheny Health NetworkAske T. Iversen - Aalborg UniversityKristine H. Allin - Aalborg UniversityParambir S. Dulai - University of California San DiegoAakash Desai - Case Western Reserve UniversityTine Jess - Aalborg University
- Publication Details
- Gastro hep advances, v 1(6), pp 1114-1121
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- DNRF148 / Danish National Research Foundation (https://doi.org/10.13039/501100001732) DK120515 / National Institute of Health (https://doi.org/10.13039/100000002) American Gastroenterology Association (https://doi.org/10.13039/100009560) Helsefonden (https://doi.org/10.13039/501100005860)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:001413372700028
- Scopus ID
- 2-s2.0-85165693172
- Other Identifier
- 991022135678004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology