Journal article
Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score
Angiology, v 71(7), pp 658-665
01 Aug 2020
PMID: 32342699
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Peripheral artery disease (PAD) is a high-risk condition for cardiovascular (CV) events, but no specific prognosis assessment tool exists. We developed an individual risk score (PAD(3D)) based on the combined predictive value for mortality, including (1) age, (2) severity of PAD, and (3) extent of atherosclerosis. Patients (n = 1310) with symptomatic PAD were followed up for a mean of 50 +/- 26 months. The cohort was randomly subdivided into a test and validation cohort. All-cause and CV mortality were prospectively analyzed for PAD(3D) score and in combination with classical risk factors. For the test and validation cohort (n = 655 each), all-cause and CV mortality were predicted (P < .001) by the PAD(3D) score. Additional inclusion of classical risk factors did not increase discrimination compared with PAD(3D) as "area under receiver-operating characteristic" curves were similar for both scores at any time point. Thus, the addition of the classical risk factors to PAD(3D) did not further improve the prognostic value. The PAD(3D) score provides a risk gradient of a 4.5-fold increase in all-cause and CV mortality. We developed a score for precise prediction of all-cause and CV mortality. The PAD(3D) score promises to allow for personalized goals in risk intervention.
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Details
- Title
- Development of a 3-Dimensional Prognostic Score for Patients With Symptomatic Peripheral Artery Disease: PAD3D Score
- Creators
- Joern F. Dopheide - University Hospital of BernHana Ramadani - University Hospital of BernLuise Adam - University Hospital of BernBrigitta Gahl - University of BernLucija Papac - University Hospital of BernJonas Veit - University Hospital of BernMathias Kaspar - University Hospital of BernMarc Schindewolf - University Hospital of BernIris Baumgartner - University Hospital of BernHeinz Drexel - Drexel University, College of Medicine
- Publication Details
- Angiology, v 71(7), pp 658-665
- Publisher
- Sage
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000533936000001
- Scopus ID
- 2-s2.0-85084846081
- Other Identifier
- 991021860782604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Peripheral Vascular Disease