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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Development of a Slow-Degrading Polymerized Curcumin Coating for Intracortical Microelectrodes
ACS applied bio materials, v 6(2), pp 806-818
20 Feb 2023
PMID: 36749645
Abstract
Intracortical microelectrodes are used with brain-computer interfaces to restore lost limb function following nervous system injury. While promising, recording ability of intracortical microelectrodes diminishes over time due, in part, to neuroinflammation. As curcumin has demonstrated neuroprotection through anti-inflammatory activity, we fabricated a 300 nm-thick intracortical microelectrode coating consisting of a polyurethane copolymer of curcumin and polyethylene glycol (PEG), denoted as poly(curcumin-PEG
carbamate) (PCPC). The uniform PCPC coating reduced silicon wafer hardness by two orders of magnitude and readily absorbed water within minutes, demonstrating that the coating is soft and hydrophilic in nature. Using an in vitro release model, curcumin eluted from the PCPC coating into the supernatant over 1 week; the majority of the coating was intact after an 8-week incubation in buffer, demonstrating potential for longer term curcumin release and softness. Assessing the efficacy of PCPC within a rat intracortical microelectrode model in vivo, there were no significant differences in tissue inflammation, scarring, neuron viability, and myelin damage between the uncoated and PCPC-coated probes. As the first study to implant nonfunctional probes with a polymerized curcumin coating, we have demonstrated the biocompatibility of a PCPC coating and presented a starting point in the design of poly(pro-curcumin) polymers as coating materials for intracortical electrodes.
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Details
- Title
- Development of a Slow-Degrading Polymerized Curcumin Coating for Intracortical Microelectrodes
- Creators
- Alexis M Ziemba - Rensselaer Polytechnic InstituteMary Clare Crochiere Woodson - Rensselaer Polytechnic InstituteJessica L Funnell - Rensselaer Polytechnic InstituteDouglas Wich - Rensselaer Polytechnic InstituteBailey Balouch - Rensselaer Polytechnic InstituteDeniz Rende - Rensselaer Polytechnic InstituteDahlia N Amato - Rensselaer Polytechnic InstituteJonathan Bao - Rensselaer Polytechnic InstituteIngrid Oprea - Rensselaer Polytechnic InstituteDominica Cao - Smith CollegeNeda Bajalo - Rensselaer Polytechnic InstituteEvon S Ereifej - Michigan UnitedJeffrey R Capadona - Louis Stokes Cleveland VA Medical CenterEdmund F Palermo - Rensselaer Polytechnic InstituteRyan J Gilbert - Rensselaer Polytechnic Institute
- Publication Details
- ACS applied bio materials, v 6(2), pp 806-818
- Publisher
- ACS Publications
- Number of pages
- 13
- Grant note
- IK2 RX002628 / RRD VA R01 NS092754 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000936073900001
- Scopus ID
- 2-s2.0-85147809019
- Other Identifier
- 991021861181104721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Materials Science, Biomaterials
- Nanoscience & Nanotechnology