Journal article
Development of a novel low-temperature deposition machine using screw extrusion to fabricate poly(L-lactide-co-glycolide) acid scaffolds
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, v 228(6), pp 593-606
01 Jun 2014
PMID: 24925551
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Scaffolds are of great importance to the success of tissue engineering. Poly(L-lactide-co-glycolide) acid is one of the most commonly used biopolymers. This study develops a novel low-temperature deposition machine using screw extrusion to fabricate poly(L-lactide-co-glycolide) acid scaffolds. The screw extrusion process of poly(L-lactide-co-glycolide) acid is analysed, and the relationship between flow rate and processing parameters is examined. This relationship provides guidelines for optimizing the processing parameters. The major components and design strategy of the fabrication system are introduced. Measures are proposed to control the leakage of materials, and optimal processing parameters are determined. The machine is also equipped with a double-screw extrusion nozzle system; preliminary results demonstrate its capacity to fabricate gradient scaffolds. Porous structure characterization using mercury porosimetry demonstrates that the fabrication system is able to fabricate poly(L-lactide-co-glycolide) acid scaffolds that are both macroporous and microporous.
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Details
- Title
- Development of a novel low-temperature deposition machine using screw extrusion to fabricate poly(L-lactide-co-glycolide) acid scaffolds
- Creators
- Changyong Liu - Tsinghua Univ, Biomfg Engn Lab, Grad Sch Shenzhen, Beijing 100084, Peoples R ChinaYu Li - Tsinghua UniversityLei Zhang - Tsinghua UniversityShengli Mi - Tsinghua UniversityYuanyuan Xu - Tsinghua UniversityWei Sun - Drexel University
- Publication Details
- Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, v 228(6), pp 593-606
- Publisher
- Sage
- Number of pages
- 14
- Grant note
- 2013M530609 / China Postdoctoral Fund; China Postdoctoral Science Foundation QN20130002 / Youth Foundation of Graduate School at Shenzhen of Tsinghua University ZDSY20120619141243215 / Shenzhen Key Laboratory of LED Packaging JCYJ201206141936 11639 / Projects of Basic Research of Shenzhen KQCX20130628155525051 / Shenzhen Peacock Plan
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000338037000007
- Scopus ID
- 2-s2.0-84905980102
- Other Identifier
- 991019167586504721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical