Journal article
Development of a novel method for synthesis of a polymeric ultrasound contrast agent
Journal of biomedical materials research. Part A, v 66(2), pp 347-355
01 Aug 2003
PMID: 12889005
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Medical ultrasound is a highly valuable diagnostic tool, especially when compared with other imaging modalities. It is a noninvasive, real-time, portable, extremely safe method compared with X-ray and inexpensive relative to magnetic resonance imaging. However, ultrasound is limited in its ability to distinguish between diseased and normal tissue. This limitation has led to the development of contrast agents. We have produced novel poly (lactic-co-glycolic) acid air-filled microcapsules that work well as ultrasound contrast agents, giving up to 24 and 25 dB enhancement when insonated in the medical imaging range at 5 and 7.5 MHz, respectively. The capsules were fabricated by modifying a double emulsion method to encapsulate camphor in the oil phase and ammonium carbonate in the aqueous phase, and later sublime the encapsulated material, leaving voids capable of being filled with a gas in their place. The role of the surfactant, poly vinyl alcohol, solution temperature, was studied and found to play an important role in the morphology of the capsules, altering their acoustic response.
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Details
- Title
- Development of a novel method for synthesis of a polymeric ultrasound contrast agent
- Creators
- Dalia M El-Sherif - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104-2875, USAMargaret A Wheatley
- Publication Details
- Journal of biomedical materials research. Part A, v 66(2), pp 347-355
- Publisher
- Wiley; United States
- Grant note
- CA52823 / NCI NIH HHS HL52901 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000184524400017
- Scopus ID
- 2-s2.0-0345600899
- Other Identifier
- 991014877658704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials