Journal article
Development of congestive heart failure and alterations in left ventricular function in patients with sustained ventricular tachyarrhythmias treated with amiodarone
The American journal of cardiology, v 60(4), pp 276-280
1987
PMID: 3303888
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The interaction between the efficacy and tolerance of amiodarone and the degree of left ventricular (LV) dysfunction was assessed in 126 patients with sustained ventricular tachyarrhythmias. In all patients radionuclide angiographic LV ejection fraction (EF) was measured before and after 8 to 12 months of amiodarone therapy. At baseline mean EF was 25 ± 13% and 86 patients had an EF of 30% or less. In patients receiving amiodarone at steady state, there was a small but significant increase in EF (23 to 26%, p < 0.05). Congestive heart failure (CHF) was present in 43 patients before amiodarone therapy. In 16 patients new (9 patients) or worsened (7 patients) CHF developed during the first year of amiodarone therapy. Development of CHF was not consistently related to a change in EF or heart rate. The clinical efficacy and tolerance of amiodarone were affected by the base-line EF and development of CHF. Efficacy and tolerance was 80% in patients with an EF of more than 30% and 60% in those with an EF of 30% or less. Among the 16 patients in whom new or worsened CHF developed, 6 (38%) died and 9 (56%) had recurrent ventricular tachyarrhythmias. Both base-line EF and development of CHF during amiodarone treatment significantly affect the prognosis in patients with ventricular tachyarrhythmias.
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Details
- Title
- Development of congestive heart failure and alterations in left ventricular function in patients with sustained ventricular tachyarrhythmias treated with amiodarone
- Creators
- Angelo A.V. De Paola - Cardiovascular Institute of the SouthLeonard N. Horowitz - Cardiovascular Institute of the SouthScott R. Spielman - Cardiovascular Institute of the SouthPatricia Brady - Cardiovascular Institute of the SouthJoel Morganroth - Cardiovascular Institute of the SouthAllan M. Greenspan - Cardiovascular Institute of the SouthHarold R. Kay - Cardiovascular Institute of the South
- Publication Details
- The American journal of cardiology, v 60(4), pp 276-280
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:A1987J486600015
- Scopus ID
- 2-s2.0-0023216094
- Other Identifier
- 991019339577704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems