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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Development of nanomaterials for bone-targeted drug delivery
Drug discovery today, v 22(9), pp 1336-1350
01 Sep 2017
PMID: 28487069
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bone is one of the major organs of the human body; it supports and protects other organs, produces blood cells, stores minerals, and regulates hormones. Therefore, disorders in bone can cause serious morbidity, complications, or mortality of patients. However, despite the significant occurrence of bone diseases, such as osteoarthritis (OA), osteoporosis (OP), non-union bone defects, bone cancer, and myeloma-related bone disease, their effective treatments remain a challenge. In this review, we highlight recent progress in the development of nanotechnology-based drug delivery for bone treatment, based on its improved delivery efficiency and safety. We summarize the most commonly used nanomaterials for bone drug delivery. We then discuss the targeting strategies of these nanomaterials to the diseased sites of bone tissue. We also highlight nanotechnology-based drug delivery to bone cells and subcellular organelles. We envision that nanotechnology-based drug delivery will serve as a powerful tool for developing treatments for currently incurable bone diseases.
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Details
- Title
- Development of nanomaterials for bone-targeted drug delivery
- Creators
- Hao Cheng - Massachusetts Institute of TechnologyAditya Chawla - Massachusetts Institute of TechnologyYafeng Yang - Massachusetts Institute of TechnologyYuxiao Li - Massachusetts Institute of TechnologyJin Zhang - Massachusetts Institute of TechnologyHae Lin Jang - Innovation Research CenterAli Khademhosseini - Innovation Research Center
- Publication Details
- Drug discovery today, v 22(9), pp 1336-1350
- Publisher
- Elsevier
- Grant note
- R01 AR057837 / NIAMS NIH HHS R01 HL099073 / NHLBI NIH HHS R01 DE021468 / NIDCR NIH HHS R21 AR070647 / NIAMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000413380400006
- Scopus ID
- 2-s2.0-85019373088
- Other Identifier
- 991021886376504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pharmacology & Pharmacy