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Journal article
Dexamethasone Suppression Test in Children with Major Depressive Disorder
Journal of the American Academy of Child and Adolescent Psychiatry, v 31(2)
Mar 1992
PMID: 1564032
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Abstract
The authors report a study of 24-hour serial cortisol determinations, measured during baseline and after the administration of 0.25 and 0.5 mg of dexamethasone in a sample of predominantly outpatient children with major depressive disorder, nonaffective psychiatric controls, and normal controls. In this sample, 24-hour baseline cortisol and the dexamethasone suppression test (DST) do not discriminate between the three groups. In addition, the authors measured 24-hour serum dexamethasone levels. There were no significant between group differences in serum dexamethasone. These results raise questions as to the utility of this test in the diagnosis of affective disorders in children. Possible reasons for the discrepancies in the dexamethasone suppression test results between in- and outpatient studies are discussed.
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Details
- Title
- Dexamethasone Suppression Test in Children with Major Depressive Disorder
- Creators
- BORIS Birmaher - University of PittsburghNEAL D. Ryan - University of PittsburghRONALD Dahl - University of PittsburghHARRIS Rabinovich - University of PittsburghPAUL Ambrosini - University of PittsburghDOUGLAS E. Williamson - University of PittsburghHANA Novacenko - University of PittsburghBEVERLY Nelson - University of PittsburghEE SING LO - University of PittsburghJOAQUIM PUIG-ANTICH - University of PittsburghBrittany Nelson - Health Management and Policy
- Publication Details
- Journal of the American Academy of Child and Adolescent Psychiatry, v 31(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]; Health Management and Policy
- Web of Science ID
- WOS:A1992HH09400016
- Scopus ID
- 2-s2.0-0026608992
- Other Identifier
- 991019184303504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics
- Psychiatry
- Psychology, Developmental